Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514305832> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1514305832 endingPage "221" @default.
- W1514305832 startingPage "215" @default.
- W1514305832 abstract "ABSTRACT Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx, and chemoresistance is an essential aspect of NPC chemotherapy failure. Sorcin has been implicated in multidrug resistance (MDR) of many types of human tumor. However, the effect and mechanism of Sorcin in MDR of human NPC is not fully clear. In this report, we silenced Sorcin in human NPC CNE2/DDP cells, and explored the role of Sorcin in MDR reversal. The results showed an increased cytotoxicity of cisplatin and intracellular accumulation of Rhodamine‐123 and glutathione depletion in Sorcin silencing CNE2/DDP cells. We also found a decreased messenger RNA and protein expression of multidrug resistance gene ( MDR1 ), multidrug resistance‐associated protein ( MRP1 ), excision repair cross‐complementing gene 1 ( ERCC1 ), glutathione S‐transferase‐π (GST‐n), RhoE , Bcl‐2 , and Survivin in Sorcin silencing CNE2/DDP cells. The increased expression of PTEN and decreased expression of p‐Akt and NF‐κB suggested that the key cellular signaling pathways were triggered by Sorcin silencing. We concluded that Sorcin silencing would contribute to establish a potent target point for MDR reversal. Anat Rec, 297:215–221, 2014. © 2013 Wiley Periodicals, Inc." @default.
- W1514305832 created "2016-06-24" @default.
- W1514305832 creator A5005197489 @default.
- W1514305832 creator A5010738468 @default.
- W1514305832 creator A5026746100 @default.
- W1514305832 creator A5058637832 @default.
- W1514305832 date "2013-12-24" @default.
- W1514305832 modified "2023-10-17" @default.
- W1514305832 title "Reversing Effect of Sorcin in the Drug Resistance of Human Nasopharyngeal Carcinoma" @default.
- W1514305832 cites W1557563759 @default.
- W1514305832 cites W1903238701 @default.
- W1514305832 cites W2007114497 @default.
- W1514305832 cites W2039693806 @default.
- W1514305832 cites W2073059281 @default.
- W1514305832 cites W2075151433 @default.
- W1514305832 cites W2102353246 @default.
- W1514305832 cites W2127988541 @default.
- W1514305832 cites W2160047329 @default.
- W1514305832 cites W2165857410 @default.
- W1514305832 doi "https://doi.org/10.1002/ar.22832" @default.
- W1514305832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24376145" @default.
- W1514305832 hasPublicationYear "2013" @default.
- W1514305832 type Work @default.
- W1514305832 sameAs 1514305832 @default.
- W1514305832 citedByCount "21" @default.
- W1514305832 countsByYear W15143058322014 @default.
- W1514305832 countsByYear W15143058322015 @default.
- W1514305832 countsByYear W15143058322017 @default.
- W1514305832 countsByYear W15143058322018 @default.
- W1514305832 countsByYear W15143058322019 @default.
- W1514305832 countsByYear W15143058322020 @default.
- W1514305832 countsByYear W15143058322021 @default.
- W1514305832 countsByYear W15143058322022 @default.
- W1514305832 countsByYear W15143058322023 @default.
- W1514305832 crossrefType "journal-article" @default.
- W1514305832 hasAuthorship W1514305832A5005197489 @default.
- W1514305832 hasAuthorship W1514305832A5010738468 @default.
- W1514305832 hasAuthorship W1514305832A5026746100 @default.
- W1514305832 hasAuthorship W1514305832A5058637832 @default.
- W1514305832 hasConcept C104317684 @default.
- W1514305832 hasConcept C114851261 @default.
- W1514305832 hasConcept C119056186 @default.
- W1514305832 hasConcept C126322002 @default.
- W1514305832 hasConcept C133936738 @default.
- W1514305832 hasConcept C185592680 @default.
- W1514305832 hasConcept C190283241 @default.
- W1514305832 hasConcept C2775975398 @default.
- W1514305832 hasConcept C2776694085 @default.
- W1514305832 hasConcept C2778239845 @default.
- W1514305832 hasConcept C2778997737 @default.
- W1514305832 hasConcept C502942594 @default.
- W1514305832 hasConcept C509974204 @default.
- W1514305832 hasConcept C54355233 @default.
- W1514305832 hasConcept C55493867 @default.
- W1514305832 hasConcept C71924100 @default.
- W1514305832 hasConcept C86803240 @default.
- W1514305832 hasConcept C98274493 @default.
- W1514305832 hasConceptScore W1514305832C104317684 @default.
- W1514305832 hasConceptScore W1514305832C114851261 @default.
- W1514305832 hasConceptScore W1514305832C119056186 @default.
- W1514305832 hasConceptScore W1514305832C126322002 @default.
- W1514305832 hasConceptScore W1514305832C133936738 @default.
- W1514305832 hasConceptScore W1514305832C185592680 @default.
- W1514305832 hasConceptScore W1514305832C190283241 @default.
- W1514305832 hasConceptScore W1514305832C2775975398 @default.
- W1514305832 hasConceptScore W1514305832C2776694085 @default.
- W1514305832 hasConceptScore W1514305832C2778239845 @default.
- W1514305832 hasConceptScore W1514305832C2778997737 @default.
- W1514305832 hasConceptScore W1514305832C502942594 @default.
- W1514305832 hasConceptScore W1514305832C509974204 @default.
- W1514305832 hasConceptScore W1514305832C54355233 @default.
- W1514305832 hasConceptScore W1514305832C55493867 @default.
- W1514305832 hasConceptScore W1514305832C71924100 @default.
- W1514305832 hasConceptScore W1514305832C86803240 @default.
- W1514305832 hasConceptScore W1514305832C98274493 @default.
- W1514305832 hasIssue "2" @default.
- W1514305832 hasLocation W15143058321 @default.
- W1514305832 hasLocation W15143058322 @default.
- W1514305832 hasOpenAccess W1514305832 @default.
- W1514305832 hasPrimaryLocation W15143058321 @default.
- W1514305832 hasRelatedWork W2345340067 @default.
- W1514305832 hasRelatedWork W2349018520 @default.
- W1514305832 hasRelatedWork W2379879358 @default.
- W1514305832 hasRelatedWork W2388731891 @default.
- W1514305832 hasRelatedWork W2521562244 @default.
- W1514305832 hasRelatedWork W2580481553 @default.
- W1514305832 hasRelatedWork W3032354441 @default.
- W1514305832 hasRelatedWork W3151141465 @default.
- W1514305832 hasRelatedWork W3171350128 @default.
- W1514305832 hasRelatedWork W4254004086 @default.
- W1514305832 hasVolume "297" @default.
- W1514305832 isParatext "false" @default.
- W1514305832 isRetracted "false" @default.
- W1514305832 magId "1514305832" @default.
- W1514305832 workType "article" @default.