FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514442302> ?p ?o ?g. }

• W1514442302 endingPage "4790" @default.
• W1514442302 startingPage "4777" @default.
• W1514442302 abstract "Breast cancer is a major cause of mortality in women. The transcription factor SNAI2 has been implicated in the pathogenesis of several types of cancer, including breast cancer of basal origin. Here we show that SNAI2 is also important in the development of breast cancer of luminal origin in MMTV-ErbB2 mice. SNAI2 deficiency leads to longer latency and fewer luminal tumors, both of these being characteristics of pretumoral origin. These effects were associated with reduced proliferation and a decreased ability to generate mammospheres in normal mammary glands. However, the capacity to metastasize was not modified. Under conditions of increased ERBB2 oncogenic activity after pregnancy plus SNAI2 deficiency, both pretumoral defects-latency and tumor load-were compensated. However, the incidence of lung metastases was dramatically reduced. Furthermore, SNAI2 was required for proper postlactational involution of the breast. At 3 days post lactational involution, the mammary glands of Snai2-deficient mice exhibited lower levels of pSTAT3 and higher levels of pAKT1, resulting in decreased apoptosis. Abundant noninvoluted ducts were still present at 30 days post lactation, with a greater number of residual ERBB2+ cells. These results suggest that this defect in involution leads to an increase in the number of susceptible target cells for transformation, to the recovery of the capacity to generate mammospheres and to an increase in the number of tumors. Our work demonstrates the participation of SNAI2 in the pathogenesis of luminal breast cancer, and reveals an unexpected connection between the processes of postlactational involution and breast tumorigenesis in Snai2-null mutant mice." @default.
• W1514442302 created "2016-06-24" @default.
• W1514442302 creator A5007852025 @default.
• W1514442302 creator A5008908552 @default.
• W1514442302 creator A5013361573 @default.
• W1514442302 creator A5016255484 @default.
• W1514442302 creator A5020425358 @default.
• W1514442302 creator A5020593430 @default.
• W1514442302 creator A5030925049 @default.
• W1514442302 creator A5032768695 @default.
• W1514442302 creator A5051937379 @default.
• W1514442302 creator A5053775618 @default.
• W1514442302 creator A5056464877 @default.
• W1514442302 creator A5063753599 @default.
• W1514442302 creator A5068063330 @default.
• W1514442302 date "2015-06-22" @default.
• W1514442302 modified "2023-10-14" @default.
• W1514442302 title "A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development" @default.
• W1514442302 cites W1520176983 @default.
• W1514442302 cites W1946429710 @default.
• W1514442302 cites W1965215187 @default.
• W1514442302 cites W1968837506 @default.
• W1514442302 cites W1969198697 @default.
• W1514442302 cites W1970140424 @default.
• W1514442302 cites W1972006609 @default.
• W1514442302 cites W1972282281 @default.
• W1514442302 cites W1976203623 @default.
• W1514442302 cites W1979440527 @default.
• W1514442302 cites W1981089896 @default.
• W1514442302 cites W1982093899 @default.
• W1514442302 cites W1982272716 @default.
• W1514442302 cites W1985995289 @default.
• W1514442302 cites W1989029691 @default.
• W1514442302 cites W1994015824 @default.
• W1514442302 cites W1999591980 @default.
• W1514442302 cites W1999991643 @default.
• W1514442302 cites W2009266190 @default.
• W1514442302 cites W2010867675 @default.
• W1514442302 cites W2014691022 @default.
• W1514442302 cites W2016362591 @default.
• W1514442302 cites W2017180102 @default.
• W1514442302 cites W2021863302 @default.
• W1514442302 cites W2033077654 @default.
• W1514442302 cites W2033509429 @default.
• W1514442302 cites W2037882440 @default.
• W1514442302 cites W2044702943 @default.
• W1514442302 cites W2049385524 @default.
• W1514442302 cites W2051178092 @default.
• W1514442302 cites W2052294963 @default.
• W1514442302 cites W2064616338 @default.
• W1514442302 cites W2069603887 @default.
• W1514442302 cites W2080483972 @default.
• W1514442302 cites W2080510160 @default.
• W1514442302 cites W2082797313 @default.
• W1514442302 cites W2085872402 @default.
• W1514442302 cites W2086854077 @default.
• W1514442302 cites W2087737747 @default.
• W1514442302 cites W2092970174 @default.
• W1514442302 cites W2093995506 @default.
• W1514442302 cites W2094836768 @default.
• W1514442302 cites W2095156669 @default.
• W1514442302 cites W2097255042 @default.
• W1514442302 cites W2101885447 @default.
• W1514442302 cites W2102514614 @default.
• W1514442302 cites W2104940735 @default.
• W1514442302 cites W2112270062 @default.
• W1514442302 cites W2117572593 @default.
• W1514442302 cites W2120044211 @default.
• W1514442302 cites W2121038486 @default.
• W1514442302 cites W2127617517 @default.
• W1514442302 cites W2134203671 @default.
• W1514442302 cites W2134299232 @default.
• W1514442302 cites W2135151730 @default.
• W1514442302 cites W2135548733 @default.
• W1514442302 cites W2136029503 @default.
• W1514442302 cites W2142226776 @default.
• W1514442302 cites W2142739240 @default.
• W1514442302 cites W2144137673 @default.
• W1514442302 cites W2146157206 @default.
• W1514442302 cites W2146235437 @default.
• W1514442302 cites W2146445411 @default.
• W1514442302 cites W2147283821 @default.
• W1514442302 cites W2149703329 @default.
• W1514442302 cites W2150488608 @default.
• W1514442302 cites W2153051750 @default.
• W1514442302 cites W2156873226 @default.
• W1514442302 cites W2159118796 @default.
• W1514442302 cites W2162647235 @default.
• W1514442302 cites W2162945499 @default.
• W1514442302 cites W2168887286 @default.
• W1514442302 cites W2182573189 @default.
• W1514442302 cites W2259802687 @default.
• W1514442302 cites W4302361206 @default.
• W1514442302 doi "https://doi.org/10.1038/onc.2015.224" @default.
• W1514442302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4560637" @default.
• W1514442302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26333823" @default.
• W1514442302 hasPublicationYear "2015" @default.
• W1514442302 type Work @default.

• next