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- W1514542682 abstract "Abstract Inflammatory bowel disease (IBD) are complex immune mediated diseases involving the interactions of many cell types including the intestinal mucosal epithelia, macrophages, T-lymphocytes (Foxp3+ Treg, Th17, Th2) and dendritic cell subsets. Induced Treg (iTreg) play an essential role in immune tolerance in the control of chronic inflammation. Current approaches to IBD therapy utilize immunosuppressive medications including methotrexate (MTX), which is hepatotoxic. Targeted drug delivery of MTX for IBD treatment may be achieved by conjugating MTX to G5 PAMAM dendrimer nanoparticles. We investigated the effect of G5-MTX12 on inflammatory responses in dextran sulfate sodium (DSS) induced IBD in BALB/c mice. We evaluated the frequency of iTreg (Foxp3+Helios- CD4+ TCRαβ+ T cells) in mesenteric lymph nodes (MLN). We found that treatment with G5-MTX induces protection of mice against DSS colitis. We found that the weight of mice treated with G5-MTX was not significantly different from naïve animals. There was a 4.7-fold increase in frequency of iTreg in mesenteric lymph nodes in G5-MTX treated mice compared to naïve animals. Thus, we achieved a therapeutic effect with targeted G5-MTX in the IBD model in mice. This targeted drug effect may be mediated by iTreg that developed under sub-immunogenic antigen presentation during intestinal inflammation. Our data may suggest that a targeted drug delivery strategy with dendrimer technology may be effective with potentially less toxicity" @default.
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- W1514542682 date "2012-05-01" @default.
- W1514542682 modified "2023-09-27" @default.
- W1514542682 title "Effect of targeted drug delivery with G5-MTX dendrimers on induced T regulatory (iTreg) CD4+ T cells in an inflammatory bowel disease (IBD) colitis model (52.1)" @default.
- W1514542682 doi "https://doi.org/10.4049/jimmunol.188.supp.52.1" @default.
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