FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514574906> ?p ?o ?g. }

• W1514574906 abstract "Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding.We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted magnetic resonance images obtained from 76 patients and 70 healthy controls. We separately searched for anatomic deviations in patients with bipolar disorder (16 patients with treatment-resistant depression, 25 with euthymia) and unipolar depression (35 patients with treatment-resistant depression).Compared with healthy controls, both groups of patients with treatment-resistant depression exhibited reduced g-SIs: in the right hemisphere among patients with bipolar disorder and in both hemispheres among those with unipolar depression. Patients with euthymic bipolar disorder did not differ significantly from depressed patients or healthy controls. Among patients with bipolar disorder who were taking lithium, we found positive correlations between current lithium dose and g-SIs in both hemispheres.We cannot estimate the extent to which the observed g-SI reductions are linked to treatment resistance and to what extent they are state-dependent. Furthermore, we cannot disentangle the impact of medications from that of the affective disorder. Finally, there is interindividual variation and overlap of g-SIs among patients and healthy controls that need to be considered when interpreting our results.Reduced global cortical folding surface appears to be characteristic of patients with treatment-resistant depression, either unipolar or bipolar. In patients with bipolar disorder, treatment with lithium may modify cortical folding surface." @default.
• W1514574906 created "2016-06-24" @default.
• W1514574906 creator A5003535842 @default.
• W1514574906 creator A5007095962 @default.
• W1514574906 creator A5010581801 @default.
• W1514574906 creator A5015688435 @default.
• W1514574906 creator A5015789775 @default.
• W1514574906 creator A5025944849 @default.
• W1514574906 creator A5028382889 @default.
• W1514574906 creator A5035699131 @default.
• W1514574906 creator A5043863759 @default.
• W1514574906 creator A5043907146 @default.
• W1514574906 creator A5048496285 @default.
• W1514574906 creator A5050669682 @default.
• W1514574906 creator A5058322812 @default.
• W1514574906 creator A5072558014 @default.
• W1514574906 creator A5085832913 @default.
• W1514574906 creator A5086515100 @default.
• W1514574906 creator A5087098619 @default.
• W1514574906 date "2009-03-01" @default.
• W1514574906 modified "2023-10-15" @default.
• W1514574906 title "Cortical folding in patients with bipolar disorder or unipolar depression." @default.
• W1514574906 cites W1535616406 @default.
• W1514574906 cites W1975764130 @default.
• W1514574906 cites W1979062697 @default.
• W1514574906 cites W1987528796 @default.
• W1514574906 cites W1988183526 @default.
• W1514574906 cites W1994638977 @default.
• W1514574906 cites W1995051494 @default.
• W1514574906 cites W1995907546 @default.
• W1514574906 cites W1999945947 @default.
• W1514574906 cites W2001981960 @default.
• W1514574906 cites W2002134117 @default.
• W1514574906 cites W2003265283 @default.
• W1514574906 cites W2004850661 @default.
• W1514574906 cites W2008694908 @default.
• W1514574906 cites W2010018607 @default.
• W1514574906 cites W2014394457 @default.
• W1514574906 cites W2015111196 @default.
• W1514574906 cites W2016629996 @default.
• W1514574906 cites W2025831311 @default.
• W1514574906 cites W2033543632 @default.
• W1514574906 cites W2047001332 @default.
• W1514574906 cites W2049299727 @default.
• W1514574906 cites W2051303178 @default.
• W1514574906 cites W2053642078 @default.
• W1514574906 cites W2059498859 @default.
• W1514574906 cites W2062224701 @default.
• W1514574906 cites W2064291553 @default.
• W1514574906 cites W2069247119 @default.
• W1514574906 cites W2070017293 @default.
• W1514574906 cites W2074243908 @default.
• W1514574906 cites W2080799291 @default.
• W1514574906 cites W2086669609 @default.
• W1514574906 cites W2091972041 @default.
• W1514574906 cites W2096245623 @default.
• W1514574906 cites W2114613490 @default.
• W1514574906 cites W2120731293 @default.
• W1514574906 cites W2123171640 @default.
• W1514574906 cites W2124828215 @default.
• W1514574906 cites W2131823335 @default.
• W1514574906 cites W2139930698 @default.
• W1514574906 cites W2142375406 @default.
• W1514574906 cites W2148239264 @default.
• W1514574906 cites W2150357704 @default.
• W1514574906 cites W2154372625 @default.
• W1514574906 cites W2156833737 @default.
• W1514574906 cites W2159011576 @default.
• W1514574906 cites W2167659819 @default.
• W1514574906 cites W2170649468 @default.
• W1514574906 cites W57359236 @default.
• W1514574906 cites W2245231029 @default.
• W1514574906 cites W2296042795 @default.
• W1514574906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2647564" @default.
• W1514574906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19270763" @default.
• W1514574906 hasPublicationYear "2009" @default.
• W1514574906 type Work @default.
• W1514574906 sameAs 1514574906 @default.
• W1514574906 citedByCount "18" @default.
• W1514574906 countsByYear W15145749062012 @default.
• W1514574906 countsByYear W15145749062013 @default.
• W1514574906 countsByYear W15145749062014 @default.
• W1514574906 countsByYear W15145749062016 @default.
• W1514574906 countsByYear W15145749062017 @default.
• W1514574906 countsByYear W15145749062018 @default.
• W1514574906 countsByYear W15145749062019 @default.
• W1514574906 countsByYear W15145749062020 @default.
• W1514574906 countsByYear W15145749062021 @default.
• W1514574906 countsByYear W15145749062022 @default.
• W1514574906 countsByYear W15145749062023 @default.
• W1514574906 crossrefType "journal-article" @default.
• W1514574906 hasAuthorship W1514574906A5003535842 @default.
• W1514574906 hasAuthorship W1514574906A5007095962 @default.
• W1514574906 hasAuthorship W1514574906A5010581801 @default.
• W1514574906 hasAuthorship W1514574906A5015688435 @default.
• W1514574906 hasAuthorship W1514574906A5015789775 @default.
• W1514574906 hasAuthorship W1514574906A5025944849 @default.
• W1514574906 hasAuthorship W1514574906A5028382889 @default.
• W1514574906 hasAuthorship W1514574906A5035699131 @default.
• W1514574906 hasAuthorship W1514574906A5043863759 @default.

• next