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- W1514667044 abstract "Summary. We studied the midbrain SERT availability in patients with major depression and assessed the relation of SERT occupancy by citalopram to the treatment response. 21 non-medicated patients with major depression and 13 healthy controls were examined by [ 123 I]-ADAM SPECT. The midbrain SERT availability (SERT V3 00 ) was calculated using individual MRI scans. In 13=21 patients SPECT was repeated 7 days after oral medication with citalopram (10 mg=day). We found no significant difference in the mean midbrain SERT availability between the studied patients with major depression and healthy controls (0.86 � 0.27 vs. 0.71 � 0.44, p ¼ 0.069). The mean SERT occupancy accounted to 61%. The degree of SERT blockade by citalopram did not correlate with the reduction in HAMD total score. Treatment with low-dosed citalopram caused individually variable occupancy of the midbrain-SERT and a rapid clinical improvement in 54% of the investigated patients." @default.
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- W1514667044 date "2006-01-01" @default.
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- W1514667044 title "Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT" @default.
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