FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514689148> ?p ?o ?g. }

• W1514689148 endingPage "214" @default.
• W1514689148 startingPage "203" @default.
• W1514689148 abstract "The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins and the advances in biochemical, molecular biological and genetic techniques which led to the elucidation of the structure, synthesis and function of this important group of extracellular matrix constituents. Particular attention is focussed on early research on the identification and assembly of the soluble precursors of collagen types I and II, and the identification of the precursor of basement membrane collagen type IV. In subsequent studies investigating the maintenance of the chick chondrocyte phenotype in culture, the influence of the extracellular milieu was found to influence markedly both cell morphology and collagen gene expression. These studies led to the discovery of collagen type X whose expression is restricted to hypertrophic chondrocytes at sites of endochondral ossification. Such research provided a prelude to investigations of mammalian endochondral ossification which is known to be aberrant in a variety of human chondrodysplasias and is reactivated in bone fracture repair and in osteoarthritis. The cloning of bovine and then human collagen type X genes facilitated studies in relevant human diseases and contributed to the discovery of mutations in the COL10A1 gene in families with metaphyseal chondrodysplasia type Schmid. Clustering of mutations in the C-terminal domain of the type X collagen molecule has now been widely documented and investigations of the pathogenic mechanisms in animal models are beginning to suggest the prospect of novel treatment strategies." @default.
• W1514689148 created "2016-06-24" @default.
• W1514689148 creator A5021521397 @default.
• W1514689148 date "2007-08-01" @default.
• W1514689148 modified "2023-09-25" @default.
• W1514689148 title "Fell-Muir Lecture: From collagen chemistry towards cell therapy - a personal journey" @default.
• W1514689148 cites W105799402 @default.
• W1514689148 cites W1513617589 @default.
• W1514689148 cites W1520036702 @default.
• W1514689148 cites W1520852262 @default.
• W1514689148 cites W1529752367 @default.
• W1514689148 cites W1552776768 @default.
• W1514689148 cites W1554182261 @default.
• W1514689148 cites W1591215074 @default.
• W1514689148 cites W1677322794 @default.
• W1514689148 cites W1709599847 @default.
• W1514689148 cites W1771308939 @default.
• W1514689148 cites W1791214172 @default.
• W1514689148 cites W1921261490 @default.
• W1514689148 cites W1963560972 @default.
• W1514689148 cites W1964047282 @default.
• W1514689148 cites W1979313922 @default.
• W1514689148 cites W1980778918 @default.
• W1514689148 cites W1994764794 @default.
• W1514689148 cites W1998883099 @default.
• W1514689148 cites W2003292237 @default.
• W1514689148 cites W2012187490 @default.
• W1514689148 cites W2025315938 @default.
• W1514689148 cites W2027534206 @default.
• W1514689148 cites W2030482221 @default.
• W1514689148 cites W2036607483 @default.
• W1514689148 cites W2041156532 @default.
• W1514689148 cites W2042012492 @default.
• W1514689148 cites W2042391634 @default.
• W1514689148 cites W2047953236 @default.
• W1514689148 cites W2048456744 @default.
• W1514689148 cites W2048642192 @default.
• W1514689148 cites W2061166048 @default.
• W1514689148 cites W2078867880 @default.
• W1514689148 cites W2078899991 @default.
• W1514689148 cites W2082454321 @default.
• W1514689148 cites W2082481602 @default.
• W1514689148 cites W2084144657 @default.
• W1514689148 cites W2085845962 @default.
• W1514689148 cites W2091462193 @default.
• W1514689148 cites W2103274083 @default.
• W1514689148 cites W2111265971 @default.
• W1514689148 cites W2141489905 @default.
• W1514689148 cites W2145335014 @default.
• W1514689148 cites W2146923243 @default.
• W1514689148 cites W2156812093 @default.
• W1514689148 cites W2162944051 @default.
• W1514689148 cites W2206505432 @default.
• W1514689148 cites W2207490821 @default.
• W1514689148 cites W2211388436 @default.
• W1514689148 cites W2212970656 @default.
• W1514689148 cites W2284341605 @default.
• W1514689148 cites W2319330567 @default.
• W1514689148 cites W2340582988 @default.
• W1514689148 cites W2414321072 @default.
• W1514689148 cites W2415365172 @default.
• W1514689148 cites W2475145769 @default.
• W1514689148 cites W2979565554 @default.
• W1514689148 cites W3155699657 @default.
• W1514689148 cites W4210739731 @default.
• W1514689148 cites W4244258380 @default.
• W1514689148 cites W4255358151 @default.
• W1514689148 cites W4302422033 @default.
• W1514689148 cites W4361866465 @default.
• W1514689148 doi "https://doi.org/10.1111/j.1365-2613.2007.00537.x" @default.
• W1514689148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2517318" @default.
• W1514689148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17696900" @default.
• W1514689148 hasPublicationYear "2007" @default.
• W1514689148 type Work @default.
• W1514689148 sameAs 1514689148 @default.
• W1514689148 citedByCount "31" @default.
• W1514689148 countsByYear W15146891482013 @default.
• W1514689148 countsByYear W15146891482014 @default.
• W1514689148 countsByYear W15146891482016 @default.
• W1514689148 countsByYear W15146891482017 @default.
• W1514689148 countsByYear W15146891482019 @default.
• W1514689148 countsByYear W15146891482020 @default.
• W1514689148 countsByYear W15146891482021 @default.
• W1514689148 countsByYear W15146891482022 @default.
• W1514689148 crossrefType "journal-article" @default.
• W1514689148 hasAuthorship W1514689148A5021521397 @default.
• W1514689148 hasBestOaLocation W15146891481 @default.
• W1514689148 hasConcept C105702510 @default.
• W1514689148 hasConcept C1491633281 @default.
• W1514689148 hasConcept C151730666 @default.
• W1514689148 hasConcept C17938293 @default.
• W1514689148 hasConcept C185592680 @default.
• W1514689148 hasConcept C189014844 @default.
• W1514689148 hasConcept C189165786 @default.
• W1514689148 hasConcept C2776193487 @default.
• W1514689148 hasConcept C2779343474 @default.
• W1514689148 hasConcept C2780550940 @default.
• W1514689148 hasConcept C2781403057 @default.

• next