FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514710040> ?p ?o ?g. }

• W1514710040 endingPage "6892" @default.
• W1514710040 startingPage "6886" @default.
• W1514710040 abstract "Receptor phosphorylation is a key step in the process of desensitization of the beta-adrenergic and other related receptors. A selective kinase (called beta-adrenergic receptor kinase, beta ARK) has been identified which phosphorylates the agonist-occupied form of the receptor. Recently the bovine beta ARK cDNA has been cloned and the highest levels of specific mRNA were found in highly innervated tissues. It was proposed that beta ARK may be primarily active on synaptic receptors. In the present study, the cDNA of human beta ARK was cloned and sequenced. The sequence was very similar to that of the bovine beta ARK (the overall amino acid homology was 98%). Very high levels of beta ARK mRNA and kinase activity were found in peripheral blood leukocytes and in several myeloid and lymphoid leukemia cell lines. Since agonist-induced beta ARK translocation is considered the first step involved in beta ARK-mediated homologous desensitization, we screened a number of G-protein-coupled receptor agonists for their ability to induce beta ARK translocation. In human mononuclear leukocytes, beta-AR agonist isoproterenol and platelet-activating factor were able to induce translocation of beta ARK from cytosol to membrane. After 20 min of exposure to isoproterenol (10 microM), the cytosolic beta ARK activity decreased to 61% of control, while membrane-associated beta ARK activity increased to 170%. 20-min exposure to platelet-activating factor (1 microM) reduced the cytosolic beta ARK activity to 42% of control with concomitant increase in membrane beta ARK activity to 214% of control. The high levels of beta ARK expression in human peripheral blood leukocytes together with the ability of isoproterenol and platelet-activating factor to induce beta ARK translocation, suggest a role for beta ARK in modulating some receptor-mediated immune functions." @default.
• W1514710040 created "2016-06-24" @default.
• W1514710040 creator A5026962347 @default.
• W1514710040 creator A5030439171 @default.
• W1514710040 creator A5044214963 @default.
• W1514710040 creator A5074984739 @default.
• W1514710040 creator A5085398262 @default.
• W1514710040 date "1992-04-01" @default.
• W1514710040 modified "2023-10-18" @default.
• W1514710040 title "High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation." @default.
• W1514710040 cites W1482398833 @default.
• W1514710040 cites W1485523393 @default.
• W1514710040 cites W1489515092 @default.
• W1514710040 cites W1517499104 @default.
• W1514710040 cites W1528193286 @default.
• W1514710040 cites W1530935792 @default.
• W1514710040 cites W1533788848 @default.
• W1514710040 cites W1561677577 @default.
• W1514710040 cites W1681220287 @default.
• W1514710040 cites W1861079720 @default.
• W1514710040 cites W1904128007 @default.
• W1514710040 cites W1945832201 @default.
• W1514710040 cites W1963816294 @default.
• W1514710040 cites W1983908525 @default.
• W1514710040 cites W2001884742 @default.
• W1514710040 cites W2029313038 @default.
• W1514710040 cites W2039137468 @default.
• W1514710040 cites W2043934481 @default.
• W1514710040 cites W2058902088 @default.
• W1514710040 cites W2060207881 @default.
• W1514710040 cites W2070738247 @default.
• W1514710040 cites W2072174432 @default.
• W1514710040 cites W2077883691 @default.
• W1514710040 cites W2081753893 @default.
• W1514710040 cites W2090695674 @default.
• W1514710040 cites W2092964019 @default.
• W1514710040 cites W2093909923 @default.
• W1514710040 cites W2100837269 @default.
• W1514710040 cites W2128020612 @default.
• W1514710040 cites W276534841 @default.
• W1514710040 doi "https://doi.org/10.1016/s0021-9258(19)50511-7" @default.
• W1514710040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1339451" @default.
• W1514710040 hasPublicationYear "1992" @default.
• W1514710040 type Work @default.
• W1514710040 sameAs 1514710040 @default.
• W1514710040 citedByCount "112" @default.
• W1514710040 countsByYear W15147100402013 @default.
• W1514710040 countsByYear W15147100402014 @default.
• W1514710040 countsByYear W15147100402015 @default.
• W1514710040 countsByYear W15147100402016 @default.
• W1514710040 countsByYear W15147100402018 @default.
• W1514710040 countsByYear W15147100402021 @default.
• W1514710040 crossrefType "journal-article" @default.
• W1514710040 hasAuthorship W1514710040A5026962347 @default.
• W1514710040 hasAuthorship W1514710040A5030439171 @default.
• W1514710040 hasAuthorship W1514710040A5044214963 @default.
• W1514710040 hasAuthorship W1514710040A5074984739 @default.
• W1514710040 hasAuthorship W1514710040A5085398262 @default.
• W1514710040 hasBestOaLocation W15147100401 @default.
• W1514710040 hasConcept C104317684 @default.
• W1514710040 hasConcept C124160383 @default.
• W1514710040 hasConcept C126322002 @default.
• W1514710040 hasConcept C134018914 @default.
• W1514710040 hasConcept C138626823 @default.
• W1514710040 hasConcept C170493617 @default.
• W1514710040 hasConcept C184235292 @default.
• W1514710040 hasConcept C185592680 @default.
• W1514710040 hasConcept C3017910909 @default.
• W1514710040 hasConcept C40465926 @default.
• W1514710040 hasConcept C55493867 @default.
• W1514710040 hasConcept C71924100 @default.
• W1514710040 hasConcept C86803240 @default.
• W1514710040 hasConcept C89560881 @default.
• W1514710040 hasConcept C90934575 @default.
• W1514710040 hasConcept C95444343 @default.
• W1514710040 hasConcept C97029542 @default.
• W1514710040 hasConceptScore W1514710040C104317684 @default.
• W1514710040 hasConceptScore W1514710040C124160383 @default.
• W1514710040 hasConceptScore W1514710040C126322002 @default.
• W1514710040 hasConceptScore W1514710040C134018914 @default.
• W1514710040 hasConceptScore W1514710040C138626823 @default.
• W1514710040 hasConceptScore W1514710040C170493617 @default.
• W1514710040 hasConceptScore W1514710040C184235292 @default.
• W1514710040 hasConceptScore W1514710040C185592680 @default.
• W1514710040 hasConceptScore W1514710040C3017910909 @default.
• W1514710040 hasConceptScore W1514710040C40465926 @default.
• W1514710040 hasConceptScore W1514710040C55493867 @default.
• W1514710040 hasConceptScore W1514710040C71924100 @default.
• W1514710040 hasConceptScore W1514710040C86803240 @default.
• W1514710040 hasConceptScore W1514710040C89560881 @default.
• W1514710040 hasConceptScore W1514710040C90934575 @default.
• W1514710040 hasConceptScore W1514710040C95444343 @default.
• W1514710040 hasConceptScore W1514710040C97029542 @default.
• W1514710040 hasIssue "10" @default.
• W1514710040 hasLocation W15147100401 @default.
• W1514710040 hasOpenAccess W1514710040 @default.
• W1514710040 hasPrimaryLocation W15147100401 @default.
• W1514710040 hasRelatedWork W1967861082 @default.

• next