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- W1514751202 abstract "This chapter discusses the role of brain histamine in pathophysiological conditions and brain diseases. Histamine is widely distributed in the human brain. The histaminergic neurons lie in the posterior hypothalamus, where about 64,000 cells form a dispersed group referred to as “nucleus tuberomammillaris.” During fetal development another transient histamine system is present in at least the rat brain, where raphe neurons contain histamine. The general organization of the histaminergic system is similar in all mature vertebrates: cell bodies located in the tuberomammillary nucleus provide almost all parts of the central nervous system (CNS) with varicose fibers containing histamine. In the human brain, histamine containing projections have so far been shown to extend to various parts of the cerebral cortex and cerebellar cortex. Histamine may regulate higher brain functions by at least two mechanisms. It enhances hippocampal N-methyl-D-aspartate (NMDA)-mediated synaptic currents in cultured hippocampal neurons, an effect mediated through the polyamine-binding site on the NMDA receptor complex. The significance of this mechanism in vivo is not yet fully understood. Histamine also switches thalamic neuronal activity from rhythmic burst firing to single-spike activity through histamine H1 and H2 receptors, thus, promoting an accurate transmission of thalamocortical relay neurons and the processing of sensory inputs and cognition. Histamine may, thus, mediate its effects through specific histamine H1, H2, and H3 receptors and through modulatory actions on other receptors." @default.
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- W1514751202 date "1998-01-01" @default.
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- W1514751202 title "Brain histamine in pathophysiological conditions and brain diseases" @default.
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- W1514751202 doi "https://doi.org/10.1016/s0165-7208(98)80033-0" @default.
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