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- W1514804926 abstract "It was once believed that once a cell had acquired a stable differentiated state, it could not change its phenotype; this is not the case now. Over the past few years, a plethora of well-documented examples have been presented whereby already differentiated cells or tissue-specific stem cells have been shown to alter their phenotype to express functional characteristics of a different tissue. This chapter examines evidence for these examples, comments on the underlying cellular and molecular mechanisms, and speculates about possible directions of research. The recent demonstration that adult stem cells, and even differentiated cells, are more versatile than previously thought means that abundant tissue for therapeutic purposes can be obtained from these cell types. Since some scientists and members of the public are averse to the use of embryonic stem cells for any form of clinical treatment, using either adult stem cells or differentiated cells induced to transdifferentiate may obviate the use of embryonic tissue. In the end, the ethical issues raised by some may not apply to transdifferentiated cells." @default.
- W1514804926 created "2016-06-24" @default.
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- W1514804926 date "2009-01-01" @default.
- W1514804926 modified "2023-09-26" @default.
- W1514804926 title "How Cells Change Their Phenotype" @default.
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- W1514804926 doi "https://doi.org/10.1016/b978-0-12-374729-7.00012-3" @default.
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