Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514881244> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1514881244 endingPage "2110" @default.
- W1514881244 startingPage "2105" @default.
- W1514881244 abstract "Human monocytes harvested from healthy donors and separated by discontinuous gradient centrifugation and adherence were highly cytotoxic to allogeneic melanoma cells, but did not affect nontumorigenic cells, as measured by lysis of the cells. After 4 days incubation of these monocytes in medium, they showed little, if any, cytolytic activity. Hydrophilic muramyl dipeptide (MDP) or lipophilic muramyl tripeptide (MTP-PE) was encapsulated within multilamellar (MLV) liposomes composed of phosphatidylserine-phosphatidylcholine. The cultured monocytes were rendered tumoricidal by interaction for 24 hr with MDP or liposomes containing soluble MDP or lipophilic MTP-PE. Moreover, freshly isolated monocytes treated for 24 hr with liposomes containing MDP or MTP-PE remained tumoricidal during culture for up to 5 days. About 1,600-times lower concentration of MDP entrapped in liposomes than of free MDP in the medium was effective for rendering monocytes tumoricidal. Similarly, about 80-times lower concentration of MTP-PE in liposomes than of free MDP was effective for the activation of monocytes. It is concluded that MLV liposomes containing MDP or MTP-PE are far more efficient in potentiating the tumoricidal activity of human monocytes than unencapsulated, free MDP." @default.
- W1514881244 created "2016-06-24" @default.
- W1514881244 creator A5009766343 @default.
- W1514881244 creator A5050041621 @default.
- W1514881244 creator A5083167574 @default.
- W1514881244 creator A5085995658 @default.
- W1514881244 date "1984-04-01" @default.
- W1514881244 modified "2023-10-14" @default.
- W1514881244 title "Potentiating effect of muramyl dipeptide and its lipophilic analog encapsulated in liposomes on tumor cell killing by human monocytes." @default.
- W1514881244 doi "https://doi.org/10.4049/jimmunol.132.4.2105" @default.
- W1514881244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6699409" @default.
- W1514881244 hasPublicationYear "1984" @default.
- W1514881244 type Work @default.
- W1514881244 sameAs 1514881244 @default.
- W1514881244 citedByCount "40" @default.
- W1514881244 countsByYear W15148812442012 @default.
- W1514881244 countsByYear W15148812442017 @default.
- W1514881244 countsByYear W15148812442018 @default.
- W1514881244 countsByYear W15148812442019 @default.
- W1514881244 countsByYear W15148812442020 @default.
- W1514881244 countsByYear W15148812442021 @default.
- W1514881244 countsByYear W15148812442022 @default.
- W1514881244 countsByYear W15148812442023 @default.
- W1514881244 crossrefType "journal-article" @default.
- W1514881244 hasAuthorship W1514881244A5009766343 @default.
- W1514881244 hasAuthorship W1514881244A5050041621 @default.
- W1514881244 hasAuthorship W1514881244A5083167574 @default.
- W1514881244 hasAuthorship W1514881244A5085995658 @default.
- W1514881244 hasBestOaLocation W15148812441 @default.
- W1514881244 hasConcept C109316439 @default.
- W1514881244 hasConcept C185154212 @default.
- W1514881244 hasConcept C185592680 @default.
- W1514881244 hasConcept C202751555 @default.
- W1514881244 hasConcept C203014093 @default.
- W1514881244 hasConcept C2776330855 @default.
- W1514881244 hasConcept C2776444769 @default.
- W1514881244 hasConcept C2778918659 @default.
- W1514881244 hasConcept C2779637612 @default.
- W1514881244 hasConcept C2781184567 @default.
- W1514881244 hasConcept C41625074 @default.
- W1514881244 hasConcept C55493867 @default.
- W1514881244 hasConcept C57409179 @default.
- W1514881244 hasConcept C73588182 @default.
- W1514881244 hasConcept C86803240 @default.
- W1514881244 hasConcept C98274493 @default.
- W1514881244 hasConceptScore W1514881244C109316439 @default.
- W1514881244 hasConceptScore W1514881244C185154212 @default.
- W1514881244 hasConceptScore W1514881244C185592680 @default.
- W1514881244 hasConceptScore W1514881244C202751555 @default.
- W1514881244 hasConceptScore W1514881244C203014093 @default.
- W1514881244 hasConceptScore W1514881244C2776330855 @default.
- W1514881244 hasConceptScore W1514881244C2776444769 @default.
- W1514881244 hasConceptScore W1514881244C2778918659 @default.
- W1514881244 hasConceptScore W1514881244C2779637612 @default.
- W1514881244 hasConceptScore W1514881244C2781184567 @default.
- W1514881244 hasConceptScore W1514881244C41625074 @default.
- W1514881244 hasConceptScore W1514881244C55493867 @default.
- W1514881244 hasConceptScore W1514881244C57409179 @default.
- W1514881244 hasConceptScore W1514881244C73588182 @default.
- W1514881244 hasConceptScore W1514881244C86803240 @default.
- W1514881244 hasConceptScore W1514881244C98274493 @default.
- W1514881244 hasIssue "4" @default.
- W1514881244 hasLocation W15148812441 @default.
- W1514881244 hasLocation W15148812442 @default.
- W1514881244 hasOpenAccess W1514881244 @default.
- W1514881244 hasPrimaryLocation W15148812441 @default.
- W1514881244 hasRelatedWork W1514881244 @default.
- W1514881244 hasRelatedWork W1521927983 @default.
- W1514881244 hasRelatedWork W1604631341 @default.
- W1514881244 hasRelatedWork W1990305055 @default.
- W1514881244 hasRelatedWork W2063267366 @default.
- W1514881244 hasRelatedWork W2096980047 @default.
- W1514881244 hasRelatedWork W2137856131 @default.
- W1514881244 hasRelatedWork W2143003884 @default.
- W1514881244 hasRelatedWork W2411021529 @default.
- W1514881244 hasRelatedWork W2539696069 @default.
- W1514881244 hasVolume "132" @default.
- W1514881244 isParatext "false" @default.
- W1514881244 isRetracted "false" @default.
- W1514881244 magId "1514881244" @default.
- W1514881244 workType "article" @default.