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- W1514960083 abstract "A thiol analog of estradiol, 17α-thioestradiol, was tested for antitumor activity in the 7, 12-dimenthylbenz( a )anthracene-induced mammary tumor-rat experimental chemotherapy system. Its effects were compared with those produced by 17α-estradiol, 17β-estradiol, testosterone propionate (TP), and 2α-methyldihydrotestosterone propionate (2α-MDTP). Of the estradiols, the largest proportion of complete remissions (CR) of all tumors in each rat was produced by 17β-estradiol (67%) followed by 17α-thioestradiol (50%) and 17α estradiol (37%). Among the androgens, 2α-MDTP yielded 70% and TP yielded 44% CR. The median duration of tumor-free status after treatment was 12, 12, 18, 33, and 8.5 weeks, respectively, for 17β-estradiol, 17α-thioestradiol, 17α-estradiol, 2α-MDTP, and TP." @default.
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- W1514960083 date "1966-11-01" @default.
- W1514960083 modified "2023-09-23" @default.
- W1514960083 title "Effects of 17-alpha-thioestradiol, 2 estradiol analogs, and 2 androgens on 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors." @default.
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