Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514972801> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1514972801 abstract "Publisher Summary This chapter discusses the translocation–phosphorylation assay used to study cofactors required for membrane or receptor targeting of G-Protein-coupled receptor kinases (GRKs). The family of GRKs comprises serine/threonine kinases involved in the phosphorylation of activated or liganded G-protein-coupled receptors. Receptor phosphorylation is a component of cellular desensitization, a state characterized by a loss of responsiveness under persistent stimulation also referred to as tachyphylaxis, tolerance, adaptation, or quenching. The rhodopsin kinase (RK) and β -adrenergic receptor kinase 1 ( β ARK1), are soluble enzymes that are observed to redistribute from the cytosol to the membranes of cells on G-protein-coupled receptor activation. The assay measures rhodopsin-mediated or G βγ -mediated kinase translocation to rod outer segment (ROS) membranes. Detection of kinase activity in supernatant versus membrane fractions is accomplished by measuring 32 P incorporation into bleached rhodopsin. The procedure outlined in the chapter is useful in determining whether translocation-like mechanisms exist for newly discovered GRKs and in identifying other components required for membrane targeting." @default.
- W1514972801 created "2016-06-24" @default.
- W1514972801 creator A5091208881 @default.
- W1514972801 date "1995-01-01" @default.
- W1514972801 modified "2023-09-23" @default.
- W1514972801 title "[13] Prenylation-dependent targeting of g-protein-coupled receptor kinases" @default.
- W1514972801 cites W1245933497 @default.
- W1514972801 cites W1482432683 @default.
- W1514972801 cites W1485523393 @default.
- W1514972801 cites W1514710040 @default.
- W1514972801 cites W1515512367 @default.
- W1514972801 cites W1533788848 @default.
- W1514972801 cites W1563425172 @default.
- W1514972801 cites W1945832201 @default.
- W1514972801 cites W1976551644 @default.
- W1514972801 cites W1993755473 @default.
- W1514972801 cites W2010955929 @default.
- W1514972801 cites W2012720568 @default.
- W1514972801 cites W2054663006 @default.
- W1514972801 cites W2063278131 @default.
- W1514972801 cites W2068032848 @default.
- W1514972801 cites W2068446924 @default.
- W1514972801 cites W2070023258 @default.
- W1514972801 cites W2075398040 @default.
- W1514972801 cites W2086617442 @default.
- W1514972801 cites W2092964019 @default.
- W1514972801 cites W2094365118 @default.
- W1514972801 cites W2103744889 @default.
- W1514972801 cites W2114164301 @default.
- W1514972801 cites W2149563853 @default.
- W1514972801 cites W2272491990 @default.
- W1514972801 cites W967892197 @default.
- W1514972801 doi "https://doi.org/10.1016/0076-6879(95)50069-3" @default.
- W1514972801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7651147" @default.
- W1514972801 hasPublicationYear "1995" @default.
- W1514972801 type Work @default.
- W1514972801 sameAs 1514972801 @default.
- W1514972801 citedByCount "0" @default.
- W1514972801 crossrefType "book-chapter" @default.
- W1514972801 hasAuthorship W1514972801A5091208881 @default.
- W1514972801 hasConcept C11960822 @default.
- W1514972801 hasConcept C135285700 @default.
- W1514972801 hasConcept C184235292 @default.
- W1514972801 hasConcept C185592680 @default.
- W1514972801 hasConcept C202033177 @default.
- W1514972801 hasConcept C2780827179 @default.
- W1514972801 hasConcept C33235085 @default.
- W1514972801 hasConcept C55493867 @default.
- W1514972801 hasConcept C62478195 @default.
- W1514972801 hasConcept C78976303 @default.
- W1514972801 hasConcept C86803240 @default.
- W1514972801 hasConcept C95444343 @default.
- W1514972801 hasConceptScore W1514972801C11960822 @default.
- W1514972801 hasConceptScore W1514972801C135285700 @default.
- W1514972801 hasConceptScore W1514972801C184235292 @default.
- W1514972801 hasConceptScore W1514972801C185592680 @default.
- W1514972801 hasConceptScore W1514972801C202033177 @default.
- W1514972801 hasConceptScore W1514972801C2780827179 @default.
- W1514972801 hasConceptScore W1514972801C33235085 @default.
- W1514972801 hasConceptScore W1514972801C55493867 @default.
- W1514972801 hasConceptScore W1514972801C62478195 @default.
- W1514972801 hasConceptScore W1514972801C78976303 @default.
- W1514972801 hasConceptScore W1514972801C86803240 @default.
- W1514972801 hasConceptScore W1514972801C95444343 @default.
- W1514972801 hasLocation W15149728011 @default.
- W1514972801 hasLocation W15149728012 @default.
- W1514972801 hasOpenAccess W1514972801 @default.
- W1514972801 hasPrimaryLocation W15149728011 @default.
- W1514972801 hasRelatedWork W1886070575 @default.
- W1514972801 hasRelatedWork W1978885306 @default.
- W1514972801 hasRelatedWork W1990796073 @default.
- W1514972801 hasRelatedWork W1995864935 @default.
- W1514972801 hasRelatedWork W2008717144 @default.
- W1514972801 hasRelatedWork W2021292760 @default.
- W1514972801 hasRelatedWork W2080451044 @default.
- W1514972801 hasRelatedWork W2128915045 @default.
- W1514972801 hasRelatedWork W2158270108 @default.
- W1514972801 hasRelatedWork W2220984210 @default.
- W1514972801 isParatext "false" @default.
- W1514972801 isRetracted "false" @default.
- W1514972801 magId "1514972801" @default.
- W1514972801 workType "book-chapter" @default.