FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1514982645> ?p ?o ?g. }

• W1514982645 endingPage "99" @default.
• W1514982645 startingPage "90" @default.
• W1514982645 abstract "Objective Elevated insulin and inflammatory cytokine levels in obesity may chronically activate signaling pathways regulating cardiac growth and contractility. Our aim was to examine the effect of obesity on cardiac PI3K isoform and Akt activation during left ventricular (LV) hypertrophy and heart failure. Methods Wild-type mice were fed normal chow or high-fat diet (HFD) for 2, 4, or 6 months. A subset of mice was subjected to chronic myocardial ischemia (MI). Results Echocardiography revealed a progressive increase in LV mass, wall thickness, and diameters in obese mice. Systolic pump function was not impaired. Increased cardiac levels of PI3Kγ, phosphorylated Akt, GSK3β, and Epac were observed after HFD for 2 months but gradually declined and were normal or reduced after 6 months, paralleled by elevated PP2A and SOCS3 levels. MI resulted in heart failure, independent of obesity, but compensatory LV hypertrophy was absent in obese mice. Histochemical analyses revealed similar increases in cardiac fibrosis, inflammation, apoptosis, and angiogenesis in lean and obese mice. Conclusions Our findings suggest that activation of Akt initially contributes to cardiac hypertrophy and that chronic metabolic and inflammatory stimulation and overexpression of inhibitory mediators decrease PI3Kγ-mediated Akt signaling and blunt compensatory hypertrophy after MI." @default.
• W1514982645 created "2016-06-24" @default.
• W1514982645 creator A5004362368 @default.
• W1514982645 creator A5006325041 @default.
• W1514982645 creator A5050550373 @default.
• W1514982645 creator A5057581712 @default.
• W1514982645 creator A5078344433 @default.
• W1514982645 date "2014-08-30" @default.
• W1514982645 modified "2023-09-26" @default.
• W1514982645 title "Differential PI3K signal transduction in obesity-associated cardiac hypertrophy and response to ischemia" @default.
• W1514982645 cites W1965575731 @default.
• W1514982645 cites W1968342451 @default.
• W1514982645 cites W1973281008 @default.
• W1514982645 cites W1978029099 @default.
• W1514982645 cites W1994101775 @default.
• W1514982645 cites W1994913289 @default.
• W1514982645 cites W2006675810 @default.
• W1514982645 cites W2017221955 @default.
• W1514982645 cites W2017588169 @default.
• W1514982645 cites W2018185839 @default.
• W1514982645 cites W2032308251 @default.
• W1514982645 cites W2035050651 @default.
• W1514982645 cites W2041693042 @default.
• W1514982645 cites W2059491453 @default.
• W1514982645 cites W2067837318 @default.
• W1514982645 cites W2084665859 @default.
• W1514982645 cites W2086673994 @default.
• W1514982645 cites W2095843559 @default.
• W1514982645 cites W2102343090 @default.
• W1514982645 cites W2113513087 @default.
• W1514982645 cites W2113976720 @default.
• W1514982645 cites W2126975783 @default.
• W1514982645 cites W2127853112 @default.
• W1514982645 cites W2132136466 @default.
• W1514982645 cites W2134141047 @default.
• W1514982645 cites W2138201763 @default.
• W1514982645 cites W2142980653 @default.
• W1514982645 cites W2144568374 @default.
• W1514982645 cites W2151764278 @default.
• W1514982645 cites W2159505514 @default.
• W1514982645 cites W2160205864 @default.
• W1514982645 cites W2166788192 @default.
• W1514982645 cites W2167634393 @default.
• W1514982645 cites W4293241767 @default.
• W1514982645 doi "https://doi.org/10.1002/oby.20888" @default.
• W1514982645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25175008" @default.
• W1514982645 hasPublicationYear "2014" @default.
• W1514982645 type Work @default.
• W1514982645 sameAs 1514982645 @default.
• W1514982645 citedByCount "13" @default.
• W1514982645 countsByYear W15149826452015 @default.
• W1514982645 countsByYear W15149826452016 @default.
• W1514982645 countsByYear W15149826452018 @default.
• W1514982645 countsByYear W15149826452019 @default.
• W1514982645 countsByYear W15149826452020 @default.
• W1514982645 countsByYear W15149826452021 @default.
• W1514982645 countsByYear W15149826452022 @default.
• W1514982645 crossrefType "journal-article" @default.
• W1514982645 hasAuthorship W1514982645A5004362368 @default.
• W1514982645 hasAuthorship W1514982645A5006325041 @default.
• W1514982645 hasAuthorship W1514982645A5050550373 @default.
• W1514982645 hasAuthorship W1514982645A5057581712 @default.
• W1514982645 hasAuthorship W1514982645A5078344433 @default.
• W1514982645 hasBestOaLocation W15149826451 @default.
• W1514982645 hasConcept C126322002 @default.
• W1514982645 hasConcept C134018914 @default.
• W1514982645 hasConcept C164705383 @default.
• W1514982645 hasConcept C167414201 @default.
• W1514982645 hasConcept C2778198053 @default.
• W1514982645 hasConcept C2780559512 @default.
• W1514982645 hasConcept C39133596 @default.
• W1514982645 hasConcept C55493867 @default.
• W1514982645 hasConcept C62478195 @default.
• W1514982645 hasConcept C71924100 @default.
• W1514982645 hasConcept C75217442 @default.
• W1514982645 hasConcept C86554907 @default.
• W1514982645 hasConcept C86803240 @default.
• W1514982645 hasConceptScore W1514982645C126322002 @default.
• W1514982645 hasConceptScore W1514982645C134018914 @default.
• W1514982645 hasConceptScore W1514982645C164705383 @default.
• W1514982645 hasConceptScore W1514982645C167414201 @default.
• W1514982645 hasConceptScore W1514982645C2778198053 @default.
• W1514982645 hasConceptScore W1514982645C2780559512 @default.
• W1514982645 hasConceptScore W1514982645C39133596 @default.
• W1514982645 hasConceptScore W1514982645C55493867 @default.
• W1514982645 hasConceptScore W1514982645C62478195 @default.
• W1514982645 hasConceptScore W1514982645C71924100 @default.
• W1514982645 hasConceptScore W1514982645C75217442 @default.
• W1514982645 hasConceptScore W1514982645C86554907 @default.
• W1514982645 hasConceptScore W1514982645C86803240 @default.
• W1514982645 hasIssue "1" @default.
• W1514982645 hasLocation W15149826451 @default.
• W1514982645 hasLocation W15149826452 @default.
• W1514982645 hasOpenAccess W1514982645 @default.
• W1514982645 hasPrimaryLocation W15149826451 @default.
• W1514982645 hasRelatedWork W1514902666 @default.
• W1514982645 hasRelatedWork W1779480512 @default.
• W1514982645 hasRelatedWork W1993774701 @default.

• next