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• W1515021808 abstract "// Moitza Principe 1,2,* , Patrizia Ceruti 1,2,* , Neng-Yao Shih 3,* , Michelle S. Chattaragada 1,2 , Simona Rolla 1,2 , Laura Conti 2,4 , Marco Bestagno 5 , Lorena Zentilin 5 , Sheng-Hui Yang 6 , Paola Migliorini 7 , Paola Cappello 1,2 , Oscar Burrone 5 and Francesco Novelli 1,2 1 Center for Experimental Research and Medical Studies (CeRMS), Azienda Universitaria Ospedaliera Città della Salute e della Scienza di Torino, Turin, Italy 2 Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy 3 National Institute of Cancer Research, National Health Research Institutes, Tainan City, Taiwan 4 Molecular Biotechnology Center (MBC), University of Turin, Turin, Italy 5 International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy 6 College of Medical Science and Technology, Taipei Medical University, Taipei City, Taiwan 7 Department of Clinical and Experimental Medicine, University of Pisa, Italy * These authors contributed equally to this work Correspondence to: Francesco Novelli, email: // Keywords : pancreatic cancer, ENO1, plasminogen, monoclonal antibody, adeno-associated virus Received : February 05, 2015 Accepted : February 22, 2015 Published : March 14, 2015 Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by rapid progression, invasiveness and resistance to treatment. We have previously demonstrated that most PDAC patients have circulating antibodies against the glycolytic enzyme alpha-enolase (ENO1), which correlates with a better response to therapy and survival. ENO1 is a metabolic enzyme, also expressed on the cell surface where it acts as a plasminogen receptor. ENO1 play a crucial role in cell invasion and metastasis by promoting plasminogen activation into plasmin, a serine-protease involved in extracellular matrix degradation. The aim of this study was to investigate the role of ENO1 in PDAC cell invasion. We observed that ENO1 was expressed on the cell surface of most PDAC cell lines. Mouse anti-human ENO1 monoclonal antibodies inhibited plasminogen-dependent invasion of human PDAC cells, and their metastatic spreading in immunosuppressed mice was inhibited. Notably, a single administration of Adeno-Associated Virus (AAV)-expressing cDNA coding for 72/1 anti-ENO1 mAb reduced the number of lung metastases in immunosuppressed mice injected with PDAC cells. Overall, these data indicate that ENO1 is involved in PDAC cell invasion, and that administration of an anti-ENO1 mAb can be exploited as a novel therapeutic option to increase the survival of metastatic PDAC patients." @default.
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• W1515021808 date "2015-03-14" @default.
• W1515021808 modified "2023-10-16" @default.
• W1515021808 title "Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells" @default.
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• W1515021808 doi "https://doi.org/10.18632/oncotarget.3572" @default.
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