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- W1515032416 abstract "The high incidence rate for hepatocellular carcinoma (HCC) in chronic liver disease and the availability of effective treatments for small tumours have suggested the need for country-based surveillance programmes in order to detect HCC at an early stage. Screening by ultrasound every 6 months is now recommended by several international and national societies. The evidence to support implementation of such programmes is critically evaluated by questioning: (1) whether there are effective treatments that require detection at an early stage, (2) whether high-risk groups can be identified, (3) whether ultrasound has sufficient diagnostic sensitivity and (4) whether surveillance will improve survival, and if so, at what cost. Decisions to implement country-based surveillance should ideally rest on results from randomised trials. This is, to some extent, the case in elderly East Asian patients with hepatitis B, but with other patient groups the recommendations rest on indirect evidence from cohorts of selected patients that probably overestimate the efficacy and underestimate the costs of these programmes." @default.
- W1515032416 created "2016-06-24" @default.
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- W1515032416 date "2011-11-29" @default.
- W1515032416 modified "2023-09-25" @default.
- W1515032416 title "What is the Value of Country-Based Surveillance Programmes?" @default.
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- W1515032416 doi "https://doi.org/10.1002/9781119962205.ch14" @default.
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