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- W1515038319 abstract "Prostate cancer is the most common non-cutaneous cancer in American men and the second most deadly (Jemal et al., 2010). One in six American men will get prostate cancer in his lifetime, and the risk increases with age. Prostate cancer progresses over the course of decades, so there is ample opportunity for prevention earlier in life. Epidemiological and laboratory studies point to vitamin D3 as a promising chemopreventative agent for prostate cancer. Vitamin D3 metabolites and analogs have been shown to induce cell cycle arrest, differentiation, and senescence in normal prostate cells and prostate cancer cells. Ongoing studies are interrogating the mechanistic effects behind vitamin D3 actions in the prostate. Additionally, clinical trials aim to investigate the potential chemopreventative and therapeutic effects of vitamin D3 metabolites and analogs, both alone and in combination with taxol-based chemotherapeutic agents. Herein we will summarize the epidemiological, laboratory, and clinical studies with vitamin D3 and the prostate and discuss how the current data supports a role for vitamin D3 in the prevention and treatment of prostate cancer." @default.
- W1515038319 created "2016-06-24" @default.
- W1515038319 creator A5005855266 @default.
- W1515038319 creator A5048914713 @default.
- W1515038319 date "2011-11-25" @default.
- W1515038319 modified "2023-10-01" @default.
- W1515038319 title "The Role of Vitamin D in the Prevention and Treatment of Prostate Cancer" @default.
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