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• W1515040786 startingPage "5876" @default.
• W1515040786 abstract "The killer cell lectin-like receptor G1 (KLRG1) is the mouse homologue of the rat mast cell function-associated Ag and contains a tyrosine-based inhibitory motif in its cytoplasmic domain. It has been demonstrated that KLRG1 is induced on activated NK cells and that KLRG1 can inhibit NK cell effector functions. In this study, we show that in naive C57BL/6 mice KLRG1 is expressed on a subset of CD44(high)CD62L(low) T cells. KLRG1 expression can be detected on a small number of V(alpha)14i NK T cells but not on CD8alphaalpha(+) intraepithelial T cells that are either TCRgammadelta(+) or TCRalphabeta(+). We also show that KLRG1 expression is dramatically induced on approximately 50% of the CD8(+) T cells during both a viral and a parasitic infection. Interestingly, during Toxoplasma gondii infection, KLRG1 is up-regulated on CD4(+) T cells. Although KLRG1 expression can be induced on both NK cells and T cells, the molecular mechanism leading to the induction of KLRG1 differs in these two subsets of cells. Indeed, the up-regulation of KLRG1 on NK cells can be driven in vivo by cytokines, whereas KLRG1 cannot be induced on CD8(+) T cells by cytokines. In addition, although induction of KLRG1 on T cells appears to require TCR engagement in vivo, TCR engagement is not sufficient for KLRG1 induction in vitro. Taken together, these data suggest that the expression and induction of KLRG1 on T cells are tightly regulated. This could have important biological consequences on T cell activation and homeostasis." @default.
• W1515040786 created "2016-06-24" @default.
• W1515040786 creator A5005534041 @default.
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• W1515040786 date "2003-06-15" @default.
• W1515040786 modified "2023-10-06" @default.
• W1515040786 title "Differential Regulation of Killer Cell Lectin-Like Receptor G1 Expression on T Cells" @default.
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• W1515040786 doi "https://doi.org/10.4049/jimmunol.170.12.5876" @default.
• W1515040786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12794113" @default.
• W1515040786 hasPublicationYear "2003" @default.
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