Matches in SemOpenAlex for { <https://semopenalex.org/work/W1515041382> ?p ?o ?g. }
- W1515041382 endingPage "1264" @default.
- W1515041382 startingPage "1255" @default.
- W1515041382 abstract "Abstract Background/Aims: Pre‐adipocyte differentiation into adipocyte is a terminal differentiation process triggered by a cascade of transcription factors. Conversely, hepatic stellate cells (HSC) can switch between lipid storing and the myofibroblast phenotype in association with liver fibrotic processes. Here, adipogenic/lipogenic‐related transcription factors and downstream‐regulated genes were evaluated in a murine HSC cell line. GRX‐HSC cells are transitional myofibroblasts that differentiate into lipocytes following retinol or indomethacin treatment. Methods/Results: Specific mRNAs were quantified by a real‐time polymerase chain reaction after 24 h or 7 days of cell culture with indomethacin or retinol. Proliferator‐activated receptorγ and Pex16 transcripts were increased either by retinol or indomethacin. Retinol induced a minor increase in C/enhancer binding proteinα transcripts, while only indomethacin increased adipsin transcripts. Conclusions: Our results showed that the myofibroblast to lipocyte phenotype switch follows partially different transcriptional pathways, according to the effector. Retinol induces lipid synthesis and storage without affecting characteristic adipocytic genes, while indomethacin treatment restores the lipocytic phenotype with increased adipisin expression." @default.
- W1515041382 created "2016-06-24" @default.
- W1515041382 creator A5002532606 @default.
- W1515041382 creator A5007804066 @default.
- W1515041382 creator A5025137225 @default.
- W1515041382 creator A5049555146 @default.
- W1515041382 creator A5061363648 @default.
- W1515041382 creator A5067182517 @default.
- W1515041382 creator A5076862804 @default.
- W1515041382 creator A5079470169 @default.
- W1515041382 date "2007-10-03" @default.
- W1515041382 modified "2023-10-15" @default.
- W1515041382 title "Hepatic stellate cell line modulates lipogenic transcription factors" @default.
- W1515041382 cites W1021717836 @default.
- W1515041382 cites W1517329574 @default.
- W1515041382 cites W1553693482 @default.
- W1515041382 cites W1568773554 @default.
- W1515041382 cites W1972742191 @default.
- W1515041382 cites W1980053858 @default.
- W1515041382 cites W1984825084 @default.
- W1515041382 cites W1992417629 @default.
- W1515041382 cites W2002535786 @default.
- W1515041382 cites W2003311380 @default.
- W1515041382 cites W2008680449 @default.
- W1515041382 cites W2011246715 @default.
- W1515041382 cites W2018103937 @default.
- W1515041382 cites W2025657436 @default.
- W1515041382 cites W2034705121 @default.
- W1515041382 cites W2038381362 @default.
- W1515041382 cites W2039619323 @default.
- W1515041382 cites W2042690181 @default.
- W1515041382 cites W2044985726 @default.
- W1515041382 cites W2050509217 @default.
- W1515041382 cites W2052156406 @default.
- W1515041382 cites W2058950883 @default.
- W1515041382 cites W2069750547 @default.
- W1515041382 cites W2071357022 @default.
- W1515041382 cites W2073413372 @default.
- W1515041382 cites W2075988136 @default.
- W1515041382 cites W2080361134 @default.
- W1515041382 cites W2087577841 @default.
- W1515041382 cites W2088404163 @default.
- W1515041382 cites W2088717034 @default.
- W1515041382 cites W2088964477 @default.
- W1515041382 cites W2089076289 @default.
- W1515041382 cites W2090129851 @default.
- W1515041382 cites W2091296342 @default.
- W1515041382 cites W2107277218 @default.
- W1515041382 cites W2115459204 @default.
- W1515041382 cites W2118881723 @default.
- W1515041382 cites W2121196456 @default.
- W1515041382 cites W2124943453 @default.
- W1515041382 cites W2141036045 @default.
- W1515041382 cites W2142824756 @default.
- W1515041382 cites W2148244700 @default.
- W1515041382 cites W2153619885 @default.
- W1515041382 cites W2260924587 @default.
- W1515041382 cites W322130708 @default.
- W1515041382 cites W9572181 @default.
- W1515041382 doi "https://doi.org/10.1111/j.1478-3231.2007.01578.x" @default.
- W1515041382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17919238" @default.
- W1515041382 hasPublicationYear "2007" @default.
- W1515041382 type Work @default.
- W1515041382 sameAs 1515041382 @default.
- W1515041382 citedByCount "32" @default.
- W1515041382 countsByYear W15150413822012 @default.
- W1515041382 countsByYear W15150413822013 @default.
- W1515041382 countsByYear W15150413822014 @default.
- W1515041382 countsByYear W15150413822015 @default.
- W1515041382 countsByYear W15150413822017 @default.
- W1515041382 countsByYear W15150413822019 @default.
- W1515041382 countsByYear W15150413822020 @default.
- W1515041382 countsByYear W15150413822021 @default.
- W1515041382 countsByYear W15150413822023 @default.
- W1515041382 crossrefType "journal-article" @default.
- W1515041382 hasAuthorship W1515041382A5002532606 @default.
- W1515041382 hasAuthorship W1515041382A5007804066 @default.
- W1515041382 hasAuthorship W1515041382A5025137225 @default.
- W1515041382 hasAuthorship W1515041382A5049555146 @default.
- W1515041382 hasAuthorship W1515041382A5061363648 @default.
- W1515041382 hasAuthorship W1515041382A5067182517 @default.
- W1515041382 hasAuthorship W1515041382A5076862804 @default.
- W1515041382 hasAuthorship W1515041382A5079470169 @default.
- W1515041382 hasConcept C104317684 @default.
- W1515041382 hasConcept C122927707 @default.
- W1515041382 hasConcept C126322002 @default.
- W1515041382 hasConcept C127561419 @default.
- W1515041382 hasConcept C127716648 @default.
- W1515041382 hasConcept C134018914 @default.
- W1515041382 hasConcept C148738053 @default.
- W1515041382 hasConcept C153911025 @default.
- W1515041382 hasConcept C170493617 @default.
- W1515041382 hasConcept C171089720 @default.
- W1515041382 hasConcept C176891718 @default.
- W1515041382 hasConcept C185592680 @default.
- W1515041382 hasConcept C187345961 @default.
- W1515041382 hasConcept C198826908 @default.
- W1515041382 hasConcept C207865475 @default.