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• W1515041923 abstract "Sepsis is the leading cause of death in medical intensive care units. Though progress has been made in the early treatment of sepsis associated with hemodynamic collapse (septic shock), little is known about the pathogenesis of delayed organ dysfunction during sepsis. A growing body of data indicates that sepsis is associated with acute changes in cell metabolism, and that mitochondria are particularly susceptible. The severity of mitochondrial pathology varies according to host and pathogen factors, and appears to correlate with loss of organ dysfunction. In this regard, low levels of cell apoptosis and mitochondrial turnover are normally observed in all metabolically active tissues; however, these homeostatic mechanisms are frequently overwhelmed during sepsis and contribute to cell and tissue pathology. Thus, a better understanding of the mechanisms regulating mitochondrial damage and repair during severe sepsis may provide new treatment options and better outcomes for this deadly disease (30-60% mortality). Herein, we present compelling evidence linking mitochondrial apoptosis pathways to sepsis-induced cell and organ failure and discuss the implications in terms of future sepsis research." @default.
• W1515041923 created "2016-06-24" @default.
• W1515041923 creator A5023334846 @default.
• W1515041923 creator A5087672793 @default.
• W1515041923 date "2008-05-01" @default.
• W1515041923 modified "2023-10-12" @default.
• W1515041923 title "Mitochondrial mechanisms of sepsis-induced organ failure." @default.
• W1515041923 cites W1488866398 @default.
• W1515041923 cites W1499659307 @default.
• W1515041923 cites W1523213544 @default.
• W1515041923 cites W1589262904 @default.
• W1515041923 cites W1598875012 @default.
• W1515041923 cites W1661840774 @default.
• W1515041923 cites W1843730344 @default.
• W1515041923 cites W1918446975 @default.
• W1515041923 cites W1946896925 @default.
• W1515041923 cites W1956327946 @default.
• W1515041923 cites W1964589582 @default.
• W1515041923 cites W1965617025 @default.
• W1515041923 cites W1970133328 @default.
• W1515041923 cites W1973109581 @default.
• W1515041923 cites W1973842058 @default.
• W1515041923 cites W1976455881 @default.
• W1515041923 cites W1977905350 @default.
• W1515041923 cites W1978555298 @default.
• W1515041923 cites W1979048203 @default.
• W1515041923 cites W1979196829 @default.
• W1515041923 cites W1979463052 @default.
• W1515041923 cites W1982654319 @default.
• W1515041923 cites W1985190814 @default.
• W1515041923 cites W1985731963 @default.
• W1515041923 cites W1986568749 @default.
• W1515041923 cites W1989289268 @default.
• W1515041923 cites W1991416315 @default.
• W1515041923 cites W1992969522 @default.
• W1515041923 cites W1995616233 @default.
• W1515041923 cites W1996155397 @default.
• W1515041923 cites W1996729081 @default.
• W1515041923 cites W1996907401 @default.
• W1515041923 cites W1998186707 @default.
• W1515041923 cites W2001163298 @default.
• W1515041923 cites W2001957697 @default.
• W1515041923 cites W2005883891 @default.
• W1515041923 cites W2006558163 @default.
• W1515041923 cites W2014983456 @default.
• W1515041923 cites W2016440344 @default.
• W1515041923 cites W2016541749 @default.
• W1515041923 cites W2020062408 @default.
• W1515041923 cites W2020295072 @default.
• W1515041923 cites W2021000405 @default.
• W1515041923 cites W2023809310 @default.
• W1515041923 cites W2025559703 @default.
• W1515041923 cites W2028419507 @default.
• W1515041923 cites W2030023942 @default.
• W1515041923 cites W2030356111 @default.
• W1515041923 cites W2033729587 @default.
• W1515041923 cites W2034231631 @default.
• W1515041923 cites W2034494651 @default.
• W1515041923 cites W2034714418 @default.
• W1515041923 cites W2038118195 @default.
• W1515041923 cites W2038535939 @default.
• W1515041923 cites W2047545717 @default.
• W1515041923 cites W2047549421 @default.
• W1515041923 cites W2048046456 @default.
• W1515041923 cites W2049927822 @default.
• W1515041923 cites W2051179657 @default.
• W1515041923 cites W2051675665 @default.
• W1515041923 cites W2054844956 @default.
• W1515041923 cites W2056872519 @default.
• W1515041923 cites W2069525370 @default.
• W1515041923 cites W2070743921 @default.
• W1515041923 cites W2070782834 @default.
• W1515041923 cites W2076057931 @default.
• W1515041923 cites W2079740726 @default.
• W1515041923 cites W2080475992 @default.
• W1515041923 cites W2081095555 @default.
• W1515041923 cites W2086283039 @default.
• W1515041923 cites W2087203965 @default.
• W1515041923 cites W2093505141 @default.
• W1515041923 cites W2093975280 @default.
• W1515041923 cites W2095537212 @default.
• W1515041923 cites W2095897782 @default.
• W1515041923 cites W2097124761 @default.
• W1515041923 cites W2101780675 @default.
• W1515041923 cites W2104431028 @default.
• W1515041923 cites W2107426649 @default.
• W1515041923 cites W2115835896 @default.
• W1515041923 cites W2121219243 @default.
• W1515041923 cites W2121391159 @default.
• W1515041923 cites W2122795906 @default.
• W1515041923 cites W2139871065 @default.
• W1515041923 cites W2144596746 @default.
• W1515041923 cites W2145577370 @default.
• W1515041923 cites W2146007259 @default.
• W1515041923 cites W2152746794 @default.
• W1515041923 cites W2152906228 @default.
• W1515041923 cites W2156320420 @default.
• W1515041923 cites W2156382457 @default.
• W1515041923 cites W2159197936 @default.
• W1515041923 cites W2159650080 @default.

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