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• W1515077934 endingPage "47" @default.
• W1515077934 startingPage "1" @default.
• W1515077934 abstract "A quality development candidate compound after a positive proof of concept clinical trial has a good chance of making it to be a marketed drug. It is the role of medicinal chemists to choose the right compounds to design and synthesize. Although toxicity is now the joint primary cause of failure of clinical candidates, there is a growing body of information about structure–toxicity relationships even as those relate to complex bioactivation pathways. With this ever-growing knowledge, it should be possible for talented medicinal chemists to design inherently safer molecules. The introduction of a broader array of in vitro toxicology studies earlier in the drug discovery process should result in high quality development candidates entering the clinic and a richer database from which future structure–toxicity relationships may be discovered. As part of medicinal chemistry design, the properties of the molecules are predicted and decisions are taken based on those predictions. From measured physical and in vitro properties, it is also possible to predict pharmacokinetic and pharmacodynamic data to estimate the dose of development compounds. Good medicinal chemistry design, taking into account both potency at the target and also the predictive toxicology discussed in this chapter, increases the probability of a project's success and heavily influences speed of reaching a clear proof of concept outcome." @default.
• W1515077934 created "2016-06-24" @default.
• W1515077934 creator A5005006695 @default.
• W1515077934 date "2011-01-01" @default.
• W1515077934 modified "2023-10-11" @default.
• W1515077934 title "Designing Drugs to Avoid Toxicity" @default.
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