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- W1515099738 abstract "This chapter discusses the analysis of drug-DNA binding data. This chapter describes the protocols for the numerical analysis of primary fluorescence and absorbance titration data that have evolved during the past decade. The rational design of new DNA binding agents requires a thorough understanding of the thermodynamics of the DNA binding of the existing drugs. Fundamental to any thermodynamic characterization of the drug–DNA interactions is the determination of binding constants. Because many DNA binding drugs exhibit large changes in absorbance or fluorescence on binding, these changes are commonly used to determine the distribution of free and bound drug in solution to construct binding isotherms that may be used to obtain binding constants. Fluorescence and absorbance spectroscopies provide a powerful means of determining drug–DNA binding constants. In addition, the chapter also describes the application of nonlinear least squares fitting methods, coupled with Monte Carlo analysis, to reliably estimate limiting optical parameters and their errors that are necessary to compute the distribution of free and bound ligand from spectroscopic data." @default.
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- W1515099738 title "Analysis of drug-DNA binding data" @default.
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- W1515099738 doi "https://doi.org/10.1016/s0076-6879(00)21202-0" @default.
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