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- W1515455412 abstract "✓Testicular torsion and ischemia-reperfusion syndrome were examined on the ipsilatcral and contralateral testi. 50 adult rats in five groups were established. The effect of two hours, 1080° unilateral testicular torsion and detorsion on the bilateral testicular tissue were evaluated by histological examination besides tissue xanthine oxidase activity and malondialdehyde, a lipid peroxidation product. Testicular torsion and reperfusion caused significant ischemia (p<0.001) that was determined by increased xanthine oxidase and lipid peroxidation on the contralateral ipsilateral and contralateral testis were significantly reduced (p<0.05) but not disappeared as the control group (p<0.001) by allopurinol which is the inhibitor of xanthine oxidase. Allopurinol reduced the ischemia on the ipsilateral testis after detorsion in the early period but there were no histological benefit 15 days later (p<0.001). There were no histological damage on the contralateral testis during 15 days after detorsion following unilateral experimental torsion in adult rats.✓Testis torsiyonu ve iskemi-reperfuzyon sendromu her iki taraf testiste incelendi. Olusturulan bes grubta (50 rat) iki saat sureyle 1080° tek tarafli testis torsiyonu ve detorsiyonunun, her iki taraf testis dokusu uzerine etkisi; doku xanthine oxidase, lipid peroksidasyon degerleri ve histopatolojik calisma ile degerlendirildi. Testis torsiyonunu ve reperfuzyonunun, hemen 15-30 dakika sonraki erken donemde karsi testiste; xanthine oxidase ve lipid peroksit yukselmesi ile kendini gosteren bir iskemiye neden oldugu goruldu (p<0,001). Iskemi-reperfuzyon sendromu etkilerini azaltabilmek amaciyla, xanthine oxidase inhibitoru olarak kullanilan Allopurinol'un, hem torsiyone, hem de karsi testiste olusan bu iskemiyi anlamli bir sekilde azalmakla beraber (p<0,05), tamamen ortadan kaldirmadigi saptandi (p<0,001). Ortalama testis biopsi degrelendirmesi (OTBD) ve ortalama seminifer tu-bulu capi (OSTC) kriterleri ile yapilan histopatolojik degerlendirmede ise; Allopurinol'un, hemen detorsiyon sonrasi erken donemde torsiyone testisi koruyor gorunmekle beraber, 15 gun sonra yapilan gec degerlendirmede, testis dokusunun siddetle zedelenmesini onlemedigi (p<0,001) tesbit edildi. Karsi testisin histopatolojik calismasinda ise, ne erken donemde ne de gec donem takiplerinde, testis dokusunda anlamli bir zedelenmenin olmadigi gorulmustur." @default.
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- W1515455412 date "2009-12-22" @default.
- W1515455412 modified "2023-09-24" @default.
- W1515455412 title "Deneysel Testis Torsiyonunda Reperfüzyon Sendromunun Yeri Ve Allopurinusile Önlenebilirliği" @default.
- W1515455412 doi "https://doi.org/10.5835/jecm.v8i2.1183" @default.
- W1515455412 hasPublicationYear "2009" @default.
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