Matches in SemOpenAlex for { <https://semopenalex.org/work/W1515456475> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1515456475 abstract "OBJECTIVE:We hypothesized that fondaparinux is safe and efficacious for venous thromboembolism (VTE) prophylaxis after acute ischemic stroke.BACKGROUND: Expert consensus guidelines recommend low dose unfractionated heparin, low molecular weight heparin or fondaparinux (Grade1B) for VTE prophylaxis in acutely ill medical patients. Fondaparinux is not recommended for VTE prophylaxis in acute ischemic stroke because of insufficient safety and efficacy data.DESIGN/METHODS: We reviewed a consecutive series of 716 patients with acute ischemic stroke receiving fondaparinux for VTE prophylaxis for 蠅48 hours during hospitalization (March 2009-October 2012). The primary outcomes were new observed symptomatic VTE events and hemorrhagic complications. Descriptive analysis and multivariate logistic regressions were performed.RESULTS:The mean age of the cohort was 68.7±14.2 years, median NIHSS score was 6 (IQR 2-13), mean duration of fondaparinux exposure was 5.6±4.3 days, 63.1% received intermittent pneumatic compression, 98.9% received antiplatelets, and 21.6% received anticoagulants. New symptomatic VTE events occurred in 9 (1.3%) patients; 6 (0.8%) had symptomatic deep venous thrombosis and 3 (0.4%) had pulmonary embolism of which one was fatal. New hemorrhagic complications occurred in 12 (1.7%) patients; 2 (0.3%) had intracranial hemorrhage, 7 (1.0%) had major extracranial hemorrhage and 3 (0.4%) had minor extracranial hemorrhage. Increased admission NIHSS score (p =0.004) was associated with VTE while duration of fondaparinux administration (p <0.001), previous history of atrial fibrillation (p =0.01) and prior stroke or TIA (p =0.04) were associated with hemorrhagic complications based on multivariate binomial logistic regression analysis.CONCLUSIONS: VTE prophylaxis with fondaparinux for acute ischemic stroke was associated with low rates of major hemorrhagic complications and symptomatic VTE events during hospital admission. Fondaparinux may be considered safe and efficacious for VTE prophylaxis after acute ischemic stroke but requires prospective validation.Study Supported by:N/A Disclosure: Dr. Ramanathan has nothing to disclose. Dr. Malhotra has nothing to disclose. Dr. Hackett has nothing to disclose. Dr. Tian has nothing to disclose. Dr. Quigley has nothing to disclose. Dr. Wright has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Tayal has nothing to disclose." @default.
- W1515456475 created "2016-06-24" @default.
- W1515456475 creator A5009457463 @default.
- W1515456475 creator A5040080142 @default.
- W1515456475 creator A5057781756 @default.
- W1515456475 creator A5072137544 @default.
- W1515456475 creator A5074246464 @default.
- W1515456475 creator A5075745450 @default.
- W1515456475 creator A5077354179 @default.
- W1515456475 creator A5089230086 @default.
- W1515456475 date "2014-04-08" @default.
- W1515456475 modified "2023-09-27" @default.
- W1515456475 title "Safety And Efficacy Of Fondaparinux For Venous Thromboembolism Prophylaxis After Acute Ischemic Stroke (P1.110)" @default.
- W1515456475 hasPublicationYear "2014" @default.
- W1515456475 type Work @default.
- W1515456475 sameAs 1515456475 @default.
- W1515456475 citedByCount "0" @default.
- W1515456475 crossrefType "journal-article" @default.
- W1515456475 hasAuthorship W1515456475A5009457463 @default.
- W1515456475 hasAuthorship W1515456475A5040080142 @default.
- W1515456475 hasAuthorship W1515456475A5057781756 @default.
- W1515456475 hasAuthorship W1515456475A5072137544 @default.
- W1515456475 hasAuthorship W1515456475A5074246464 @default.
- W1515456475 hasAuthorship W1515456475A5075745450 @default.
- W1515456475 hasAuthorship W1515456475A5077354179 @default.
- W1515456475 hasAuthorship W1515456475A5089230086 @default.
- W1515456475 hasConcept C126322002 @default.
- W1515456475 hasConcept C127413603 @default.
- W1515456475 hasConcept C141071460 @default.
- W1515456475 hasConcept C2776265017 @default.
- W1515456475 hasConcept C2776877702 @default.
- W1515456475 hasConcept C2777557582 @default.
- W1515456475 hasConcept C2780011451 @default.
- W1515456475 hasConcept C2780645631 @default.
- W1515456475 hasConcept C2780868729 @default.
- W1515456475 hasConcept C2991741193 @default.
- W1515456475 hasConcept C42219234 @default.
- W1515456475 hasConcept C71924100 @default.
- W1515456475 hasConcept C78519656 @default.
- W1515456475 hasConceptScore W1515456475C126322002 @default.
- W1515456475 hasConceptScore W1515456475C127413603 @default.
- W1515456475 hasConceptScore W1515456475C141071460 @default.
- W1515456475 hasConceptScore W1515456475C2776265017 @default.
- W1515456475 hasConceptScore W1515456475C2776877702 @default.
- W1515456475 hasConceptScore W1515456475C2777557582 @default.
- W1515456475 hasConceptScore W1515456475C2780011451 @default.
- W1515456475 hasConceptScore W1515456475C2780645631 @default.
- W1515456475 hasConceptScore W1515456475C2780868729 @default.
- W1515456475 hasConceptScore W1515456475C2991741193 @default.
- W1515456475 hasConceptScore W1515456475C42219234 @default.
- W1515456475 hasConceptScore W1515456475C71924100 @default.
- W1515456475 hasConceptScore W1515456475C78519656 @default.
- W1515456475 hasOpenAccess W1515456475 @default.
- W1515456475 hasRelatedWork W1531059049 @default.
- W1515456475 hasRelatedWork W1979129991 @default.
- W1515456475 hasRelatedWork W1981192265 @default.
- W1515456475 hasRelatedWork W2024409212 @default.
- W1515456475 hasRelatedWork W2047982246 @default.
- W1515456475 hasRelatedWork W2049379999 @default.
- W1515456475 hasRelatedWork W2112071008 @default.
- W1515456475 hasRelatedWork W2548134605 @default.
- W1515456475 hasRelatedWork W2567520591 @default.
- W1515456475 hasRelatedWork W2803100812 @default.
- W1515456475 hasRelatedWork W2986888121 @default.
- W1515456475 hasRelatedWork W3082011734 @default.
- W1515456475 hasRelatedWork W3085017852 @default.
- W1515456475 hasRelatedWork W3106600827 @default.
- W1515456475 hasRelatedWork W3124627571 @default.
- W1515456475 hasRelatedWork W3157076821 @default.
- W1515456475 hasRelatedWork W3190747619 @default.
- W1515456475 hasRelatedWork W3206399243 @default.
- W1515456475 hasRelatedWork W2048288188 @default.
- W1515456475 hasRelatedWork W2399357704 @default.
- W1515456475 hasVolume "82" @default.
- W1515456475 isParatext "false" @default.
- W1515456475 isRetracted "false" @default.
- W1515456475 magId "1515456475" @default.
- W1515456475 workType "article" @default.