FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1515501634> ?p ?o ?g. }

• W1515501634 abstract "Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) develop hypertension and stroke at earlier ages than do nonmalignant SHRSP. Our previous findings suggested that reactive oxygen species were involved in the development of stroke in this strain. Nitric oxide (NO) which is more released at ischemia, might play a crucial role in stroke development by producing peroxynitrite, a neurotoxic substance. This study investigated whether the development of cerebrovascular lesion in M-SHRSP could be assessed by the fluctuation of serum NO(x) concentration, and whether peroxynitrite is associated with brain damage. Serum NO(x) levels were examined using an automated NO detector. Stroke-onset was temporally assessed according to a known method: changes in body weight, water intake, and neurologic symptoms. Cerebral lesions were confirmed by magnetic resonance imaging (MRI), and Evans blue extravasation at autopsy. MRI taken just after estimated stroke onset disclosed brain lesions. The baseline serum NO(x) level remained at 15-18 micromol/l, but the level gradually increased prior to stroke, and significantly at stroke onset. A marked rise in serum NO(x) occurred subsequently at poststroke. Immunohistochemical staining of nitrotyrosine, a peroxynitrite marker, was detected around vessels, neuronal cells and parenchyma in cerebral lesions. Stroke occurred in 50% of male M-SHRSP at 80 days of age. In conclusion, this study provides the first evidence for fluctuation of serum NO(x) at the onset of spontaneous stroke accompanying the appearance of peroxynitrite in brain lesions. Monitoring serum NO(x) would serve to assess the development of brain lesions at least in spontaneous stroke model." @default.
• W1515501634 created "2016-06-24" @default.
• W1515501634 creator A5005590499 @default.
• W1515501634 creator A5013154107 @default.
• W1515501634 creator A5024832078 @default.
• W1515501634 creator A5032150734 @default.
• W1515501634 creator A5048371664 @default.
• W1515501634 creator A5075989323 @default.
• W1515501634 creator A5078914063 @default.
• W1515501634 date "2002-09-01" @default.
• W1515501634 modified "2023-09-23" @default.
• W1515501634 title "Fluctuation of serum NOx concentration at stroke onset in a rat spontaneous stroke model (M-SHRSP)" @default.
• W1515501634 cites W1919291000 @default.
• W1515501634 cites W1969941249 @default.
• W1515501634 cites W1971256560 @default.
• W1515501634 cites W1972438028 @default.
• W1515501634 cites W1976555160 @default.
• W1515501634 cites W1978136794 @default.
• W1515501634 cites W1988718932 @default.
• W1515501634 cites W1990802251 @default.
• W1515501634 cites W1991833325 @default.
• W1515501634 cites W1991986418 @default.
• W1515501634 cites W1995459142 @default.
• W1515501634 cites W1999767931 @default.
• W1515501634 cites W2002337245 @default.
• W1515501634 cites W2007277444 @default.
• W1515501634 cites W2015463429 @default.
• W1515501634 cites W2039626545 @default.
• W1515501634 cites W2051154431 @default.
• W1515501634 cites W2051894873 @default.
• W1515501634 cites W2058137293 @default.
• W1515501634 cites W2059022032 @default.
• W1515501634 cites W2059061809 @default.
• W1515501634 cites W2059640915 @default.
• W1515501634 cites W2080572230 @default.
• W1515501634 cites W2090094331 @default.
• W1515501634 cites W2093987846 @default.
• W1515501634 cites W2104371820 @default.
• W1515501634 cites W2110779213 @default.
• W1515501634 cites W2120339303 @default.
• W1515501634 cites W2120826336 @default.
• W1515501634 cites W2127203967 @default.
• W1515501634 cites W2146843161 @default.
• W1515501634 cites W2163293935 @default.
• W1515501634 cites W2164910167 @default.
• W1515501634 cites W2166342281 @default.
• W1515501634 cites W2171192249 @default.
• W1515501634 cites W2265110805 @default.
• W1515501634 cites W3099349907 @default.
• W1515501634 doi "https://doi.org/10.1016/s0006-8993(02)02975-x" @default.
• W1515501634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12213310" @default.
• W1515501634 hasPublicationYear "2002" @default.
• W1515501634 type Work @default.
• W1515501634 sameAs 1515501634 @default.
• W1515501634 citedByCount "18" @default.
• W1515501634 countsByYear W15155016342012 @default.
• W1515501634 countsByYear W15155016342013 @default.
• W1515501634 crossrefType "journal-article" @default.
• W1515501634 hasAuthorship W1515501634A5005590499 @default.
• W1515501634 hasAuthorship W1515501634A5013154107 @default.
• W1515501634 hasAuthorship W1515501634A5024832078 @default.
• W1515501634 hasAuthorship W1515501634A5032150734 @default.
• W1515501634 hasAuthorship W1515501634A5048371664 @default.
• W1515501634 hasAuthorship W1515501634A5075989323 @default.
• W1515501634 hasAuthorship W1515501634A5078914063 @default.
• W1515501634 hasConcept C126322002 @default.
• W1515501634 hasConcept C127413603 @default.
• W1515501634 hasConcept C134018914 @default.
• W1515501634 hasConcept C142724271 @default.
• W1515501634 hasConcept C164705383 @default.
• W1515501634 hasConcept C181199279 @default.
• W1515501634 hasConcept C185592680 @default.
• W1515501634 hasConcept C2777622882 @default.
• W1515501634 hasConcept C2778784160 @default.
• W1515501634 hasConcept C2779385521 @default.
• W1515501634 hasConcept C2780645631 @default.
• W1515501634 hasConcept C2780795997 @default.
• W1515501634 hasConcept C2781156865 @default.
• W1515501634 hasConcept C42219234 @default.
• W1515501634 hasConcept C519581460 @default.
• W1515501634 hasConcept C55493867 @default.
• W1515501634 hasConcept C71924100 @default.
• W1515501634 hasConcept C78519656 @default.
• W1515501634 hasConceptScore W1515501634C126322002 @default.
• W1515501634 hasConceptScore W1515501634C127413603 @default.
• W1515501634 hasConceptScore W1515501634C134018914 @default.
• W1515501634 hasConceptScore W1515501634C142724271 @default.
• W1515501634 hasConceptScore W1515501634C164705383 @default.
• W1515501634 hasConceptScore W1515501634C181199279 @default.
• W1515501634 hasConceptScore W1515501634C185592680 @default.
• W1515501634 hasConceptScore W1515501634C2777622882 @default.
• W1515501634 hasConceptScore W1515501634C2778784160 @default.
• W1515501634 hasConceptScore W1515501634C2779385521 @default.
• W1515501634 hasConceptScore W1515501634C2780645631 @default.
• W1515501634 hasConceptScore W1515501634C2780795997 @default.
• W1515501634 hasConceptScore W1515501634C2781156865 @default.
• W1515501634 hasConceptScore W1515501634C42219234 @default.
• W1515501634 hasConceptScore W1515501634C519581460 @default.
• W1515501634 hasConceptScore W1515501634C55493867 @default.
• W1515501634 hasConceptScore W1515501634C71924100 @default.

• next