FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1515511446> ?p ?o ?g. }

• W1515511446 endingPage "8019" @default.
• W1515511446 startingPage "8014" @default.
• W1515511446 abstract "The carbocyanine dye 3,3'-dipropylthiodicarbocyanine iodide has been used to investigate changes in membrane potential (Em) which occur upon binding of complement proteins C5b-9 to the plasma membrane of blood platelets. Gel-filtered platelets exposed to C5b6 and C7 in serum-free medium show no change in Em from that of controls, as indicated by either 3,3,'-dipropylthiodicarbocyanine iodide fluorescence or by the distribution of [14C]tetraphenylphosphonium bromide. Addition of complement proteins C8 and C9 to the C5b67 platelets results in partial depolarization of Em, which spontaneously repolarizes to basal levels within 15-20 min at 37 degrees C. Under these conditions, C5b-9-treated platelets show no increase in lysis over complement-free controls. Isotonic replacement of external sodium by either potassium or choline alters both the rate and extent of membrane depolarization and inhibits the platelets' capacity to repolarize after C5b-9 assembly. Repolarization of Em to basal levels is also completely blocked by addition of ouabain, confirming that this recovery is mediated by the plasma membrane Na+/K+ pump. These results demonstrate that membrane binding of the C5b-9 proteins can induce a transient change in Em when bound to the plasma membrane at a sublytic concentration, providing a mechanism for target cell activation by these potentially cytolytic proteins." @default.
• W1515511446 created "2016-06-24" @default.
• W1515511446 creator A5004352838 @default.
• W1515511446 creator A5026350256 @default.
• W1515511446 date "1985-07-01" @default.
• W1515511446 modified "2023-10-18" @default.
• W1515511446 title "Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential." @default.
• W1515511446 cites W1491684453 @default.
• W1515511446 cites W1493339267 @default.
• W1515511446 cites W149526388 @default.
• W1515511446 cites W1499977326 @default.
• W1515511446 cites W1506059273 @default.
• W1515511446 cites W1547563617 @default.
• W1515511446 cites W1596846507 @default.
• W1515511446 cites W1953113640 @default.
• W1515511446 cites W1973060534 @default.
• W1515511446 cites W1977030018 @default.
• W1515511446 cites W1998185507 @default.
• W1515511446 cites W2007673973 @default.
• W1515511446 cites W2008548563 @default.
• W1515511446 cites W2013345905 @default.
• W1515511446 cites W2015539099 @default.
• W1515511446 cites W2023479689 @default.
• W1515511446 cites W2034342778 @default.
• W1515511446 cites W2041192203 @default.
• W1515511446 cites W2055585702 @default.
• W1515511446 cites W2057764550 @default.
• W1515511446 cites W2071723011 @default.
• W1515511446 cites W2075559081 @default.
• W1515511446 cites W2075797460 @default.
• W1515511446 cites W2078466641 @default.
• W1515511446 cites W2080125478 @default.
• W1515511446 cites W2085137730 @default.
• W1515511446 cites W2088796182 @default.
• W1515511446 cites W2117129602 @default.
• W1515511446 cites W2130327650 @default.
• W1515511446 cites W2142955857 @default.
• W1515511446 cites W2145358621 @default.
• W1515511446 cites W2163494154 @default.
• W1515511446 cites W2304287624 @default.
• W1515511446 cites W2330436374 @default.
• W1515511446 cites W2415697340 @default.
• W1515511446 cites W2433386067 @default.
• W1515511446 cites W4313313401 @default.
• W1515511446 doi "https://doi.org/10.1016/s0021-9258(17)39556-x" @default.
• W1515511446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4008487" @default.
• W1515511446 hasPublicationYear "1985" @default.
• W1515511446 type Work @default.
• W1515511446 sameAs 1515511446 @default.
• W1515511446 citedByCount "84" @default.
• W1515511446 countsByYear W15155114462012 @default.
• W1515511446 countsByYear W15155114462013 @default.
• W1515511446 countsByYear W15155114462014 @default.
• W1515511446 countsByYear W15155114462015 @default.
• W1515511446 countsByYear W15155114462016 @default.
• W1515511446 countsByYear W15155114462018 @default.
• W1515511446 countsByYear W15155114462019 @default.
• W1515511446 countsByYear W15155114462020 @default.
• W1515511446 countsByYear W15155114462021 @default.
• W1515511446 countsByYear W15155114462022 @default.
• W1515511446 countsByYear W15155114462023 @default.
• W1515511446 crossrefType "journal-article" @default.
• W1515511446 hasAuthorship W1515511446A5004352838 @default.
• W1515511446 hasAuthorship W1515511446A5026350256 @default.
• W1515511446 hasBestOaLocation W15155114461 @default.
• W1515511446 hasConcept C104317684 @default.
• W1515511446 hasConcept C111684460 @default.
• W1515511446 hasConcept C112313634 @default.
• W1515511446 hasConcept C12554922 @default.
• W1515511446 hasConcept C127716648 @default.
• W1515511446 hasConcept C159654299 @default.
• W1515511446 hasConcept C181911157 @default.
• W1515511446 hasConcept C185592680 @default.
• W1515511446 hasConcept C188082640 @default.
• W1515511446 hasConcept C203014093 @default.
• W1515511446 hasConcept C2993443003 @default.
• W1515511446 hasConcept C4141045 @default.
• W1515511446 hasConcept C41625074 @default.
• W1515511446 hasConcept C55493867 @default.
• W1515511446 hasConcept C86803240 @default.
• W1515511446 hasConcept C89560881 @default.
• W1515511446 hasConcept C95444343 @default.
• W1515511446 hasConceptScore W1515511446C104317684 @default.
• W1515511446 hasConceptScore W1515511446C111684460 @default.
• W1515511446 hasConceptScore W1515511446C112313634 @default.
• W1515511446 hasConceptScore W1515511446C12554922 @default.
• W1515511446 hasConceptScore W1515511446C127716648 @default.
• W1515511446 hasConceptScore W1515511446C159654299 @default.
• W1515511446 hasConceptScore W1515511446C181911157 @default.
• W1515511446 hasConceptScore W1515511446C185592680 @default.
• W1515511446 hasConceptScore W1515511446C188082640 @default.
• W1515511446 hasConceptScore W1515511446C203014093 @default.
• W1515511446 hasConceptScore W1515511446C2993443003 @default.
• W1515511446 hasConceptScore W1515511446C4141045 @default.
• W1515511446 hasConceptScore W1515511446C41625074 @default.
• W1515511446 hasConceptScore W1515511446C55493867 @default.
• W1515511446 hasConceptScore W1515511446C86803240 @default.
• W1515511446 hasConceptScore W1515511446C89560881 @default.

• next