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- W1515563890 abstract "OBJECTIVE: To show neuroanatomical differences in grey matter (GM) between individuals with amyotrophic lateral sclerosis (ALS), ALS with mild cognitive impairment (ALS-MCI), and ALS with dementia (ALS-FTD).BACKGROUND: ALS patients have shown a spectrum of cognitive impairment, ranging from cognitively normal to severe problems with behavior, executive functioning, and language. GM atrophy also is present in these patients, but few studies have examined whether atrophy tracks the entire spectrum of cognitive difficulty in ALS.DESIGN: We assessed 55 consecutive patients with varying levels of cognitive impairment (no impairment=31, MCI=8, FTD=16) and a matched group of healthy controls (n=35). Each participant had high-resolution magnetic resonance imaging (MRI) scans that we used to analyze GM density. We performed two-sample t-tests in SPM8 to compare groups. Clusters with a height threshold of p<0.01 (uncorrected), a cluster extent of 50 voxels, and a peak voxel threshold of p<0.001 (uncorrected) were considered significant.RESULTS: All ALS groups showed GM atrophy relative to a control group. ALS-MCI and ALS-FTD had atrophy relative to controls focused in prefrontal cortex, with ALS-FTD atrophy also extending both dorsomedially and laterally in prefrontal cortex, as well as extending to inferior parietal cortex and superior temporal cortex. ALS-MCI patients had reduced GM in orbitofrontal and ventromedial-prefrontal cortices relative to ALS, and ALS-FTD had more GM atrophy than the ALS-MCI, including medial prefrontal cortex, anterior cingulate, and lateral prefrontal cortex.CONCLUSIONS: Cross-sectional studies showed that greater cognitive difficulty tracks progressive GM atrophy in ALS, ALS-MCI and ALS-FTD. Atrophy of cognitively impaired ALS patients was focused in frontal cortex, extending into temporal and parietal lobes as cognition in ALS declines.Study Supported by: NIH Grants AG17586, NS44266, AG15116, AG32953, NS53488 and the Wyncote Foundation. Disclosure: Dr. Olm has nothing to disclose. Dr. Elman has nothing to disclose. Dr. McCluskey has nothing to disclose. Dr. McMillan has nothing to disclose. Dr. Grossman has received personal compensation for activities with Allon Therapeutics." @default.
- W1515563890 created "2016-06-24" @default.
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- W1515563890 date "2014-04-08" @default.
- W1515563890 modified "2023-09-25" @default.
- W1515563890 title "Cognitive Decline Is Associated with Progressive Grey Matter Disease in Amyotrophic Lateral Sclerosis (ALS) (P2.175)" @default.
- W1515563890 hasPublicationYear "2014" @default.
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