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• W1515671058 abstract "The principal contribution described in this chapter is the identification and initial characterization of two distinct promoters for human NOS1 gene transcription. Although closely linked, these promoters are separable, in that they can independently drive the expression of appropriately linked reporter genes in transfection systems. The demonstration of independent promoter activities renders it unlikely that alternative splicing of a single primary transcript produces the heterogeneity in NOS1 mRNA structure reflected in the cDNA clones pNOS5′1 and pNOS5′2. The number of NOS1 expressing neurons and the level of NOS1 mRNA rise sharply then decline during development of the chicken tectum. Recent pharmacological studies indicate that induction of NOS1 might be crucial to establishing the appropriate pattern of synaptic connections in the tectum. Moreover induction of NOS1 in the tectum appears to require projection of axons from retinal ganglion cells. Potential mechanisms for these alterations in NOS1 gene expression during CNS development is anticipated to emerge through studies of NOS1 promoter function. It is also important to characterize the genetic basis for NOS1 gene expression in the CNS because the NOS1 promoter is apt to provide a valuable research tool. NOS+ neurons are selectively resistant to degeneration in Huntington's chorea and Alzheimer's disease, during ischemia, and in response to assaults by the neurotoxin quinolinic acid. In addition, NOS1 is dramatically induced in spinal motor neurons as well as in dorsal root ganglia, in response to avulsion and proximal transection, respectively." @default.
• W1515671058 created "2016-06-24" @default.
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• W1515671058 date "1995-01-01" @default.
• W1515671058 modified "2023-09-27" @default.
• W1515671058 title "Transcription of the Human Neuronal Nitric Oxide Synthase Gene in the Central Nervous System is Mediated by Multiple Promoters" @default.
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• W1515671058 doi "https://doi.org/10.1016/s1054-3589(08)61082-0" @default.
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