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- W1515703466 endingPage "89" @default.
- W1515703466 startingPage "55" @default.
- W1515703466 abstract "DNA methylation is a common epigenetic modification found in eukaryotic organisms ranging from fungi to mammals. Over the past 15 years, a number of eukaryotic DNA methyltransferases have been identified from various model organisms. These enzymes exhibit distinct biochemical properties and biological functions, partly due to their structural differences. The highly variable N-terminal extensions of these enzymes harbor various evolutionarily conserved domains and motifs, some of which have been shown to be involved in functional specializations. DNA methylation has divergent functions in different organisms, consistent with the notion that it is a dynamically evolving mechanism that can be adapted to fulfill various functions. Genetic studies using model organisms have provided evidence suggesting the progressive integration of DNA methylation into eukaryotic developmental programs during evolution." @default.
- W1515703466 created "2016-06-24" @default.
- W1515703466 creator A5039864753 @default.
- W1515703466 creator A5068248239 @default.
- W1515703466 date "2004-01-01" @default.
- W1515703466 modified "2023-10-15" @default.
- W1515703466 title "Structure and Function of Eukaryotic DNA Methyltransferases" @default.
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