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• W1515704871 abstract "Biomimetic membrane arrays that mimic biological cell membranes, with the ability to support membrane protein or peptide reconstitutions, are increasingly being recognised as an important platform for biomedical applications. High-throughput screening (HTS) systems based on membrane arrays may become an important alternative to cell-based screening of potential drug candidates on membrane protein targets (Fang et al., 2006). The advantages of such membrane arrays are the ability to address specific drug-on-target interactions and to identify potential unintended effects on cell membrane properties or interactions with secondary unwanted proteins. The transport properties of channel proteins or peptides may also be utilized in novel sensor based platforms such as stochastic sensors for detection of organic molecules in solutions for use in medicine or environmental monitoring (Ashkenasy et al., 2005; Capone et al., 2007; Gu et al., 1999; Nikolelis & Siontorou, 1996). Provided that the effective membrane area can be scaled sufficiently, protein channel-based membrane arrays may be applied in larger scale biomedical applications. An example is aquaporins, which are water selective proteins that function to filter water, for example in the mammalian kidney. Aquaporin-based large scale biomembranes may be envisaged as the new generation hemodialysis systems for kidney patients, or be applied in general water purification systems. Biomimetic membrane peptide or protein based arrays are however not currently applied in commercial biomedical or biotechnological applications. While creation of a single lipid bilayer membrane across a Teflon aperture is a well-established technique, the creation of biomembrane arrays comprises a relatively new concept in the scientific field of biomimetics. The reasons are amongst others associated with the inherent difficulties of reproducible creating planar suspended membranes and a generally low stability of established biomembranes. Moreover, amongst the general challenges in biomimetic membrane design is scale up of membrane effective areas to create stable and addressable membrane arrays with long lifetimes (> days). This chapter will give an overview of recent advances in the development of planar biomimetic membrane arrays, and will discuss strategies and general challenges for creating stable and scalable biomembranes for use in biomedical applications." @default.
• W1515704871 created "2016-06-24" @default.
• W1515704871 creator A5014146647 @default.
• W1515704871 creator A5086269649 @default.
• W1515704871 date "2011-04-26" @default.
• W1515704871 modified "2023-10-04" @default.
• W1515704871 title "Creating Scalable and Addressable Biomimetic Membrane Arrays in Biomedicine" @default.
• W1515704871 cites W111700602 @default.
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• W1515704871 cites W1492349014 @default.
• W1515704871 cites W1508315241 @default.
• W1515704871 cites W1539168006 @default.
• W1515704871 cites W1678350171 @default.
• W1515704871 cites W1967641814 @default.
• W1515704871 cites W1971901439 @default.
• W1515704871 cites W1973424761 @default.
• W1515704871 cites W1973469606 @default.
• W1515704871 cites W1974010403 @default.
• W1515704871 cites W1977480169 @default.
• W1515704871 cites W1979696046 @default.
• W1515704871 cites W1980638347 @default.
• W1515704871 cites W1984732791 @default.
• W1515704871 cites W1988901585 @default.
• W1515704871 cites W1989648759 @default.
• W1515704871 cites W1996068289 @default.
• W1515704871 cites W1996935462 @default.
• W1515704871 cites W1997274910 @default.
• W1515704871 cites W1998913854 @default.
• W1515704871 cites W2000130623 @default.
• W1515704871 cites W2002450452 @default.
• W1515704871 cites W2002764861 @default.
• W1515704871 cites W2003327691 @default.
• W1515704871 cites W2007871511 @default.
• W1515704871 cites W2008976548 @default.
• W1515704871 cites W2009556301 @default.
• W1515704871 cites W2011903250 @default.
• W1515704871 cites W2014442062 @default.
• W1515704871 cites W2015103159 @default.
• W1515704871 cites W2015784287 @default.
• W1515704871 cites W2016237935 @default.
• W1515704871 cites W2016343967 @default.
• W1515704871 cites W2017703080 @default.
• W1515704871 cites W2021058770 @default.
• W1515704871 cites W2022107727 @default.
• W1515704871 cites W2024307474 @default.
• W1515704871 cites W2025643464 @default.
• W1515704871 cites W2028416885 @default.
• W1515704871 cites W2031245531 @default.
• W1515704871 cites W2033795884 @default.
• W1515704871 cites W2034615100 @default.
• W1515704871 cites W2034970769 @default.
• W1515704871 cites W2035863713 @default.
• W1515704871 cites W2042699679 @default.
• W1515704871 cites W2044422060 @default.
• W1515704871 cites W2048843077 @default.
• W1515704871 cites W2055425903 @default.
• W1515704871 cites W2056942158 @default.
• W1515704871 cites W2058082730 @default.
• W1515704871 cites W2058315784 @default.
• W1515704871 cites W2059275344 @default.
• W1515704871 cites W2061718144 @default.
• W1515704871 cites W2062401722 @default.
• W1515704871 cites W2062811598 @default.
• W1515704871 cites W2064367141 @default.
• W1515704871 cites W2064718761 @default.
• W1515704871 cites W2064816775 @default.
• W1515704871 cites W2066339316 @default.
• W1515704871 cites W2069633295 @default.
• W1515704871 cites W2069727454 @default.
• W1515704871 cites W2071771855 @default.
• W1515704871 cites W2072519289 @default.
• W1515704871 cites W2075700523 @default.
• W1515704871 cites W2077602216 @default.
• W1515704871 cites W2080604099 @default.
• W1515704871 cites W2080800399 @default.
• W1515704871 cites W2085544730 @default.
• W1515704871 cites W2086523113 @default.
• W1515704871 cites W2087459096 @default.
• W1515704871 cites W2089435638 @default.
• W1515704871 cites W2092945847 @default.
• W1515704871 cites W2099446866 @default.
• W1515704871 cites W2101934167 @default.
• W1515704871 cites W2103191515 @default.
• W1515704871 cites W2108952399 @default.
• W1515704871 cites W2122613015 @default.
• W1515704871 cites W2153425709 @default.
• W1515704871 cites W2164929179 @default.
• W1515704871 cites W2165440836 @default.
• W1515704871 cites W2330393579 @default.
• W1515704871 cites W2409574218 @default.
• W1515704871 cites W2499330961 @default.
• W1515704871 cites W2021670068 @default.
• W1515704871 doi "https://doi.org/10.5772/14000" @default.
• W1515704871 hasPublicationYear "2011" @default.
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