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• W1515783523 abstract "Erectile dysfunction (ED) is a widespread problem affecting many men across all age groups and it is more than a serious quality of life problem for sexually active men. Over 30 million men suffer from ED in the U.S. 1 and it is becoming a public health issue. The prevalence of ED is very high and is expected to raise considerably over the next 25 years, impacting more than 300 million men by 2025 2. ED is defined as the persistent inability to maintain or achieve a penile erection sufficient for satisfactory sexual performance. Its etiology is multifactorial. Various aspects affect the expression/degree of ED and risk factors include age, diabetes mellitus, neurologic diseases, smoking and cardiovascular diseases (CVD), among others 3. Although the disorder has been described for more than 1000 years, the molecular basis and mechanisms of ED have yet to be completely understood. In the last 4 decades, elucidation of the macroscopic structures of the erectile system 4-5 ushered in a new era of therapeutic options for erectile disorders. Later, new insights into erectile neurotransmission, 6 essentially the nitric oxide (NO) pathway, 7 resulted in rational alternatives as a treatment 8. Nowadays, advances in gene discovery and intensive research regarding different mechanisms which could lead to ED have increased the working knowledge of the pathways involved in this condition. This chapter will describe the basic penile physiology and the emergent mechanisms associated to pathophisiology of vasculogenic ED. Penile anatomy and physiology will be summarized in order to review the new insights regarding pathways and critical modifications observed in ED condition." @default.
• W1515783523 created "2016-06-24" @default.
• W1515783523 creator A5028789700 @default.
• W1515783523 creator A5030845503 @default.
• W1515783523 date "2012-02-29" @default.
• W1515783523 modified "2023-09-24" @default.
• W1515783523 title "Mechanisms in Erectile Function and Dysfunction: An Overview" @default.
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