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• W1515892394 abstract "Maize (Zea mays) is a widely cultivated cereal that has been safely consumed by humans and animals for centuries. Transgenic or genetically engineered insect-resistant and herbicide-tolerant maize, are commercially grown on a broad scale. Event TC1507 (OECD unique identifier: DAS-Ø15Ø7-1) or the Herculex®(#) I trait, an insect-resistant and herbicide-tolerant maize expressing Cry1F and PAT proteins, has been registered for commercial cultivation in the US since 2001. A science-based safety assessment was conducted on TC1507 prior to commercialization. The safety assessment addressed allergenicity; acute oral toxicity; subchronic toxicity; substantial equivalence with conventional comparators, as well as environmental impact. Results from biochemical, physicochemical, and in silico investigations supported the conclusion that Cry1F and PAT proteins are unlikely to be either allergenic or toxic to humans. Also, findings from toxicological and animal feeding studies supported that maize with TC1507 is as safe and nutritious as conventional maize. Maize with TC1507 is not expected to behave differently than conventional maize in terms of its potential for invasiveness, gene flow to wild and weedy relatives, or impact on non-target organisms. These safety conclusions regarding TC1507 were acknowledged by over 20 regulatory agencies including United States Environment Protection Agency (US EPA), US Department of Agriculture (USDA), Canadian Food Inspection Agency (CFIA), and European Food Safety Authority (EFSA) before authorizing cultivation and/or food and feed uses. A comprehensive review of the safety studies on TC1507, as well as some benefits, are presented here to serve as a reference for regulatory agencies and decision makers in other countries where authorization of TC1507 is or will be pursued." @default.
• W1515892394 created "2016-06-24" @default.
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• W1515892394 date "2015-04-03" @default.
• W1515892394 modified "2023-09-27" @default.
• W1515892394 title "Transgenic maize event TC1507: Global status of food, feed, and environmental safety" @default.
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• W1515892394 doi "https://doi.org/10.1080/21645698.2015.1054093" @default.
• W1515892394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5033190" @default.
• W1515892394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26018138" @default.
• W1515892394 hasPublicationYear "2015" @default.
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