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- W1515957440 abstract "Publisher Summary This chapter focuses on methodologies that can be utilized to determine the sites of N-linked carbohydrates on a G protein-coupled receptor (GPCR), as well as techniques directed toward elucidating the potential roles of N-linked glycosylation. The role of N-linked glycosylation in the expression and function of GPCRs, as well as other cell surface receptors and proteins, has been an area of active investigation for many years. The one functional role of N-linked carbohydrates that may be general to all glycoproteins is their facilitation of the proper folding of the protein. Indeed, two ER chaperone proteins, calnexin and caheticulin, have been shown to facilitate the folding of many glycoproteins through an interaction with nascent glycoproteins primarily through their N-linked carbohydrates. However, the degree to which a given GPCR depends on N-linked carbohydrates for folding may vary. For example, rLHR is expressed at the cell surface, albeit at very low levels, and is fully functional, suggesting that although the N-linked carbohydrates may facilitate the folding of the rLHR, they are not essential. In contrast, the structurally related rFSHR absolutely requires N-linked carbohydrates to fold into a mature conformation." @default.
- W1515957440 created "2016-06-24" @default.
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- W1515957440 date "2002-01-01" @default.
- W1515957440 modified "2023-09-24" @default.
- W1515957440 title "N-linked carbohydrates on G protein-coupled receptors: Mapping sites of attachment and determining functional roles" @default.
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- W1515957440 doi "https://doi.org/10.1016/s0076-6879(02)43136-9" @default.
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