FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1516049943> ?p ?o ?g. }

• W1516049943 endingPage "12303" @default.
• W1516049943 startingPage "12291" @default.
• W1516049943 abstract "// Yue Zhang 1, * , Fu-Jun Zhao 2, * , Li-Lan Chen 1 , Luo-Qiao Wang 1 , Kenneth P. Nephew 3 , Ying-Li Wu 4 , Shu Zhang 1 1 Department of Obstetrics and Gynecology, RenJi Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Key Laboratory of Gynecologic Oncology, Shanghai, 200127, China 2 Department of Urology, Shanghai First People’s Hospital, Shanghai Jiao-Tong University, Shanghai, 200080, China 3 Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA 4 Department of Pathophysiology, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China * These authors contributed eqully to this work Correspondence to: Shu Zhang, e-mail: drzhangshu@126.com Ying-Li Wu, e-mail: wuyingli@shsmu.edu.cn Keywords: ovarian cancer, miR-373, Rab22a, invasion, metastasis Received: July 19, 2014      Accepted: October 06, 2014      Published: November 07, 2014 ABSTRACT Metastasis is major cause of mortality in patients with ovarian cancer. MiR-373 has been shown to play pivotal roles in tumorigenesis and metastasis; however, a role for miR-373 in ovarian cancer has not been investigated. In this study, we show that the miR-373 expression is down-regulated in human epithelial ovarian cancer (EOC) and inversely correlated with clinical stage and histological grade. Ectopic overexpression of miR-373 in human EOC cells suppressed cell invasion in vitro and metastasis in vivo , and the epithelial–mesenchymal transition process. Silencing the expression of miR-373 resulted in an increased migration and invasion of EOC cells. Using integrated bioinformatics analysis, gene expression arrays, and luciferase assay, we identified Rab22a as a direct and functional target of miR-373 in EOC cells. Expression levels of miR-373 were inversely correlated with Rab22a protein levels in human EOC tissues. Rab22a knockdown inhibited invasion and migration of EOC cells, increased E-cadherin expression, and suppressed the expression of N-cadherin. Moreover, overexpression of Rab22a abrogated miR-373-induced invasion and migration of EOC cells. Taken together, these results demonstrate that miR-373 suppresses EOC invasion and metastasis by directly targeting Rab22a gene, a new potential therapeutic target in EOC." @default.
• W1516049943 created "2016-06-24" @default.
• W1516049943 creator A5010776860 @default.
• W1516049943 creator A5019977312 @default.
• W1516049943 creator A5026350208 @default.
• W1516049943 creator A5061888144 @default.
• W1516049943 creator A5070447902 @default.
• W1516049943 creator A5080330069 @default.
• W1516049943 creator A5084939652 @default.
• W1516049943 date "2014-11-07" @default.
• W1516049943 modified "2023-09-27" @default.
• W1516049943 title "MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer" @default.
• W1516049943 cites W1764964215 @default.
• W1516049943 cites W1948503740 @default.
• W1516049943 cites W198097152 @default.
• W1516049943 cites W1988989137 @default.
• W1516049943 cites W1999161170 @default.
• W1516049943 cites W1999967473 @default.
• W1516049943 cites W2003729329 @default.
• W1516049943 cites W2009190733 @default.
• W1516049943 cites W2012462812 @default.
• W1516049943 cites W2013798280 @default.
• W1516049943 cites W2014082684 @default.
• W1516049943 cites W2023914962 @default.
• W1516049943 cites W2037945496 @default.
• W1516049943 cites W2039213901 @default.
• W1516049943 cites W2053599512 @default.
• W1516049943 cites W2055302693 @default.
• W1516049943 cites W2056360747 @default.
• W1516049943 cites W2066751026 @default.
• W1516049943 cites W2075711878 @default.
• W1516049943 cites W2076356585 @default.
• W1516049943 cites W2086246241 @default.
• W1516049943 cites W2092400840 @default.
• W1516049943 cites W2093027716 @default.
• W1516049943 cites W2126378395 @default.
• W1516049943 cites W2130959624 @default.
• W1516049943 cites W2134701923 @default.
• W1516049943 cites W2138784667 @default.
• W1516049943 cites W2139419679 @default.
• W1516049943 cites W2141552214 @default.
• W1516049943 cites W2145021085 @default.
• W1516049943 cites W2147326690 @default.
• W1516049943 cites W2148889205 @default.
• W1516049943 cites W2151027196 @default.
• W1516049943 cites W2158219017 @default.
• W1516049943 cites W22471996 @default.
• W1516049943 doi "https://doi.org/10.18632/oncotarget.2577" @default.
• W1516049943 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4323008" @default.
• W1516049943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25460499" @default.
• W1516049943 hasPublicationYear "2014" @default.
• W1516049943 type Work @default.
• W1516049943 sameAs 1516049943 @default.
• W1516049943 citedByCount "63" @default.
• W1516049943 countsByYear W15160499432015 @default.
• W1516049943 countsByYear W15160499432016 @default.
• W1516049943 countsByYear W15160499432017 @default.
• W1516049943 countsByYear W15160499432018 @default.
• W1516049943 countsByYear W15160499432019 @default.
• W1516049943 countsByYear W15160499432020 @default.
• W1516049943 countsByYear W15160499432021 @default.
• W1516049943 countsByYear W15160499432022 @default.
• W1516049943 countsByYear W15160499432023 @default.
• W1516049943 crossrefType "journal-article" @default.
• W1516049943 hasAuthorship W1516049943A5010776860 @default.
• W1516049943 hasAuthorship W1516049943A5019977312 @default.
• W1516049943 hasAuthorship W1516049943A5026350208 @default.
• W1516049943 hasAuthorship W1516049943A5061888144 @default.
• W1516049943 hasAuthorship W1516049943A5070447902 @default.
• W1516049943 hasAuthorship W1516049943A5080330069 @default.
• W1516049943 hasAuthorship W1516049943A5084939652 @default.
• W1516049943 hasBestOaLocation W15160499431 @default.
• W1516049943 hasConcept C121608353 @default.
• W1516049943 hasConcept C126322002 @default.
• W1516049943 hasConcept C143998085 @default.
• W1516049943 hasConcept C2779013556 @default.
• W1516049943 hasConcept C2780427987 @default.
• W1516049943 hasConcept C2781018059 @default.
• W1516049943 hasConcept C29537977 @default.
• W1516049943 hasConcept C502942594 @default.
• W1516049943 hasConcept C555283112 @default.
• W1516049943 hasConcept C67082663 @default.
• W1516049943 hasConcept C71924100 @default.
• W1516049943 hasConceptScore W1516049943C121608353 @default.
• W1516049943 hasConceptScore W1516049943C126322002 @default.
• W1516049943 hasConceptScore W1516049943C143998085 @default.
• W1516049943 hasConceptScore W1516049943C2779013556 @default.
• W1516049943 hasConceptScore W1516049943C2780427987 @default.
• W1516049943 hasConceptScore W1516049943C2781018059 @default.
• W1516049943 hasConceptScore W1516049943C29537977 @default.
• W1516049943 hasConceptScore W1516049943C502942594 @default.
• W1516049943 hasConceptScore W1516049943C555283112 @default.
• W1516049943 hasConceptScore W1516049943C67082663 @default.
• W1516049943 hasConceptScore W1516049943C71924100 @default.
• W1516049943 hasIssue "23" @default.
• W1516049943 hasLocation W15160499431 @default.
• W1516049943 hasLocation W15160499432 @default.
• W1516049943 hasLocation W15160499433 @default.

• next