Matches in SemOpenAlex for { <https://semopenalex.org/work/W1516195360> ?p ?o ?g. }
- W1516195360 endingPage "648" @default.
- W1516195360 startingPage "635" @default.
- W1516195360 abstract "Cigarette smoking has reached epidemic proportions within many regions of the world and remains the highest risk factor for chronic obstructive pulmonary disease (COPD) and lung cancer. Squamous cell lung cancer is commonly detected in heavy smokers, where the risk of developing lung cancer is not solely defined by tobacco consumption. Although therapies that target common driver mutations in adenocarcinomas are showing some promise, they are proving ineffective in smoking-related squamous cell lung cancer. Since COPD is characterized by an excessive inflammatory and oxidative stress response, this review details how aberrant innate, adaptive and systemic inflammatory processes can contribute to lung cancer susceptibility in COPD. Activated leukocytes release increasing levels of proteases and free radicals as COPD progresses and tertiary lymphoid aggregates accumulate with increasing severity. Reactive oxygen species promote formation of reactive carbonyls that are not only tumourigenic through initiating DNA damage, but can directly alter the function of regulatory proteins involved in host immunity and tumour suppressor functions. Systemic inflammation is also markedly increased during infective exacerbations in COPD and the interplay between tumour-promoting serum amyloid A (SAA) and IL-17A is discussed. SAA is also an endogenous allosteric modifier of FPR2 expressed on immune and epithelial cells, and the therapeutic potential of targeting this receptor is proposed as a novel strategy for COPD-lung cancer overlap." @default.
- W1516195360 created "2016-06-24" @default.
- W1516195360 creator A5008084743 @default.
- W1516195360 creator A5019519742 @default.
- W1516195360 creator A5040119940 @default.
- W1516195360 creator A5052397789 @default.
- W1516195360 creator A5054845690 @default.
- W1516195360 creator A5060211723 @default.
- W1516195360 creator A5079475266 @default.
- W1516195360 date "2015-07-08" @default.
- W1516195360 modified "2023-10-13" @default.
- W1516195360 title "COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link" @default.
- W1516195360 cites W1529023379 @default.
- W1516195360 cites W1531140346 @default.
- W1516195360 cites W1540026419 @default.
- W1516195360 cites W1574172480 @default.
- W1516195360 cites W1580033279 @default.
- W1516195360 cites W1580333051 @default.
- W1516195360 cites W1606413143 @default.
- W1516195360 cites W1797677206 @default.
- W1516195360 cites W1905245397 @default.
- W1516195360 cites W1965013629 @default.
- W1516195360 cites W1965237664 @default.
- W1516195360 cites W1969944763 @default.
- W1516195360 cites W1969945860 @default.
- W1516195360 cites W1970784817 @default.
- W1516195360 cites W1971088574 @default.
- W1516195360 cites W1971825415 @default.
- W1516195360 cites W1977492069 @default.
- W1516195360 cites W1977628719 @default.
- W1516195360 cites W1978499139 @default.
- W1516195360 cites W1978857579 @default.
- W1516195360 cites W1979628343 @default.
- W1516195360 cites W1980008048 @default.
- W1516195360 cites W1982153589 @default.
- W1516195360 cites W1984379998 @default.
- W1516195360 cites W1987628377 @default.
- W1516195360 cites W1988151751 @default.
- W1516195360 cites W1990674750 @default.
- W1516195360 cites W1992697535 @default.
- W1516195360 cites W1992724001 @default.
- W1516195360 cites W1993441515 @default.
- W1516195360 cites W1994685997 @default.
- W1516195360 cites W1995147812 @default.
- W1516195360 cites W1996753343 @default.
- W1516195360 cites W1999128589 @default.
- W1516195360 cites W2000181213 @default.
- W1516195360 cites W2004186675 @default.
- W1516195360 cites W2004979724 @default.
- W1516195360 cites W2004999743 @default.
- W1516195360 cites W2007095144 @default.
- W1516195360 cites W2009671306 @default.
- W1516195360 cites W2010874881 @default.
- W1516195360 cites W2011445291 @default.
- W1516195360 cites W2015677100 @default.
- W1516195360 cites W2018281862 @default.
- W1516195360 cites W2021002328 @default.
- W1516195360 cites W2021346058 @default.
- W1516195360 cites W2023898364 @default.
- W1516195360 cites W2030749349 @default.
- W1516195360 cites W2031033693 @default.
- W1516195360 cites W2031235464 @default.
- W1516195360 cites W2032353554 @default.
- W1516195360 cites W2034620904 @default.
- W1516195360 cites W2036327819 @default.
- W1516195360 cites W2037385288 @default.
- W1516195360 cites W2040695321 @default.
- W1516195360 cites W2043843025 @default.
- W1516195360 cites W2044029244 @default.
- W1516195360 cites W2044433987 @default.
- W1516195360 cites W2045616259 @default.
- W1516195360 cites W2046768931 @default.
- W1516195360 cites W2046972425 @default.
- W1516195360 cites W2048351247 @default.
- W1516195360 cites W2049193229 @default.
- W1516195360 cites W2050070510 @default.
- W1516195360 cites W2050105240 @default.
- W1516195360 cites W2053968039 @default.
- W1516195360 cites W2054472394 @default.
- W1516195360 cites W2055309245 @default.
- W1516195360 cites W2058539497 @default.
- W1516195360 cites W2059227176 @default.
- W1516195360 cites W2060436620 @default.
- W1516195360 cites W2062016307 @default.
- W1516195360 cites W2064497840 @default.
- W1516195360 cites W2070619903 @default.
- W1516195360 cites W2071392303 @default.
- W1516195360 cites W2076559871 @default.
- W1516195360 cites W2079175213 @default.
- W1516195360 cites W2086561195 @default.
- W1516195360 cites W2087190470 @default.
- W1516195360 cites W2087218656 @default.
- W1516195360 cites W2087861952 @default.
- W1516195360 cites W2091588921 @default.
- W1516195360 cites W2092755980 @default.
- W1516195360 cites W2098414192 @default.
- W1516195360 cites W2098888044 @default.
- W1516195360 cites W2099900951 @default.