FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1516233473> ?p ?o ?g. }

• W1516233473 endingPage "22" @default.
• W1516233473 startingPage "1916" @default.
• W1516233473 abstract "Intrahepatic tumor is a major problem in clinical oncology. While direct intravascular infusions provide high local drug concentrations and variable rates of tumor response, they are limited by technical considerations and complications. In this study, we have tested whether high portal venous and hepatic arterial concentrations of 5-fluorouracil (5-FUra) can be achieved by administering drug via peritoneal dialysis. Four patients with metastatic colon carcinoma had a Tenckhoff catheter surgically implanted. During dialysis therapy with 4 mM 5-FUra, simultaneous samples of peritoneal fluid and of portal venous, hepatic venous, and peripheral venous, and arterial blood were obtained, and 5-FUra concentrations were determined. Mean peak portal vein drug concentrations were 60 microM and exceeded the measured concentrations in the other vessels. Total drug exposures as measured by concentration x time (mM x min) during Exchange 1 were: portal, 3.8 +/- 0.65; hepatic vein, 0.97 +/- 0.44; peripheral vein, 0.90 +/- 0.32; and arterial, 1.1 +/- 0.26. During Exchange 7, total drug exposures were: portal, 6.3 +/- 1.4; hepatic vein, 2.5 +/- 1.3; peripheral vein, 2.3 +/- 1.1; and arterial, 2.7 +/- .85. The fraction of i.p. drug that exited the peritoneal cavity through the portal venous system ranged from 0.29 to 1.0. This variation resulted in part from uncertainty in estimating portal blood flow and gastrointestinal drug elimination. Calculated hepatic extraction was 67% (range, 0.23 to 0.89). Extrahepatic metabolism was demonstrated. Measured 5-FUra concentrations compared favorably to values predicted by a pharmacokinetic model for 5-FUra. Dialysis therapy (i.p.) with 5-FUra provides a means of achieving high drug concentrations for treating both i.p. and intrahepatic tumor. Further clinical testing of this route of administration is warranted." @default.
• W1516233473 created "2016-06-24" @default.
• W1516233473 creator A5026863845 @default.
• W1516233473 creator A5043918821 @default.
• W1516233473 creator A5045720971 @default.
• W1516233473 creator A5057983478 @default.
• W1516233473 creator A5063353346 @default.
• W1516233473 creator A5065139905 @default.
• W1516233473 date "1981-05-01" @default.
• W1516233473 modified "2023-10-16" @default.
• W1516233473 title "Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans." @default.
• W1516233473 cites W140374241 @default.
• W1516233473 cites W1485041712 @default.
• W1516233473 cites W1787282773 @default.
• W1516233473 cites W1876804437 @default.
• W1516233473 cites W1979404467 @default.
• W1516233473 cites W1980290766 @default.
• W1516233473 cites W2015170916 @default.
• W1516233473 cites W2016889589 @default.
• W1516233473 cites W2019997281 @default.
• W1516233473 cites W2020805271 @default.
• W1516233473 cites W2023841872 @default.
• W1516233473 cites W2032178037 @default.
• W1516233473 cites W2045290689 @default.
• W1516233473 cites W2046927975 @default.
• W1516233473 cites W2054915493 @default.
• W1516233473 cites W2057384089 @default.
• W1516233473 cites W2065539121 @default.
• W1516233473 cites W2072832749 @default.
• W1516233473 cites W2076404390 @default.
• W1516233473 cites W2080921068 @default.
• W1516233473 cites W2084312933 @default.
• W1516233473 cites W2089455830 @default.
• W1516233473 cites W2092758006 @default.
• W1516233473 cites W2145134976 @default.
• W1516233473 cites W2288064897 @default.
• W1516233473 cites W2396200506 @default.
• W1516233473 cites W2411963720 @default.
• W1516233473 cites W2413509722 @default.
• W1516233473 cites W2416150607 @default.
• W1516233473 cites W2417397815 @default.
• W1516233473 cites W43396622 @default.
• W1516233473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7214359" @default.
• W1516233473 hasPublicationYear "1981" @default.
• W1516233473 type Work @default.
• W1516233473 sameAs 1516233473 @default.
• W1516233473 citedByCount "95" @default.
• W1516233473 countsByYear W15162334732013 @default.
• W1516233473 countsByYear W15162334732014 @default.
• W1516233473 countsByYear W15162334732015 @default.
• W1516233473 countsByYear W15162334732016 @default.
• W1516233473 countsByYear W15162334732017 @default.
• W1516233473 countsByYear W15162334732018 @default.
• W1516233473 countsByYear W15162334732019 @default.
• W1516233473 countsByYear W15162334732020 @default.
• W1516233473 countsByYear W15162334732021 @default.
• W1516233473 countsByYear W15162334732022 @default.
• W1516233473 countsByYear W15162334732023 @default.
• W1516233473 crossrefType "journal-article" @default.
• W1516233473 hasAuthorship W1516233473A5026863845 @default.
• W1516233473 hasAuthorship W1516233473A5043918821 @default.
• W1516233473 hasAuthorship W1516233473A5045720971 @default.
• W1516233473 hasAuthorship W1516233473A5057983478 @default.
• W1516233473 hasAuthorship W1516233473A5063353346 @default.
• W1516233473 hasAuthorship W1516233473A5065139905 @default.
• W1516233473 hasConcept C126322002 @default.
• W1516233473 hasConcept C126894567 @default.
• W1516233473 hasConcept C2777202286 @default.
• W1516233473 hasConcept C2777214474 @default.
• W1516233473 hasConcept C2778808290 @default.
• W1516233473 hasConcept C2779056158 @default.
• W1516233473 hasConcept C2780359995 @default.
• W1516233473 hasConcept C71924100 @default.
• W1516233473 hasConcept C90924648 @default.
• W1516233473 hasConceptScore W1516233473C126322002 @default.
• W1516233473 hasConceptScore W1516233473C126894567 @default.
• W1516233473 hasConceptScore W1516233473C2777202286 @default.
• W1516233473 hasConceptScore W1516233473C2777214474 @default.
• W1516233473 hasConceptScore W1516233473C2778808290 @default.
• W1516233473 hasConceptScore W1516233473C2779056158 @default.
• W1516233473 hasConceptScore W1516233473C2780359995 @default.
• W1516233473 hasConceptScore W1516233473C71924100 @default.
• W1516233473 hasConceptScore W1516233473C90924648 @default.
• W1516233473 hasIssue "5" @default.
• W1516233473 hasLocation W15162334731 @default.
• W1516233473 hasOpenAccess W1516233473 @default.
• W1516233473 hasPrimaryLocation W15162334731 @default.
• W1516233473 hasRelatedWork W1516233473 @default.
• W1516233473 hasRelatedWork W2045907309 @default.
• W1516233473 hasRelatedWork W2099770034 @default.
• W1516233473 hasRelatedWork W2348703365 @default.
• W1516233473 hasRelatedWork W2353514142 @default.
• W1516233473 hasRelatedWork W2378805612 @default.
• W1516233473 hasRelatedWork W2394332557 @default.
• W1516233473 hasRelatedWork W2413398123 @default.
• W1516233473 hasRelatedWork W2416659860 @default.
• W1516233473 hasRelatedWork W4247191820 @default.
• W1516233473 hasVolume "41" @default.

• next