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• W1516328542 abstract "Background and objective The hypoxic inhalation test (HIT) accurately predicts air travel hypoxaemia, but availability is limited. We assessed whether oxygen saturation (SpO2) during HIT can be predicted by simple measures of lung function and exercise-induced hypoxaemia. Methods Analysis of all patients who had HIT and lung function testing performed between January 2005 and April 2010. Prior to HIT, SpO2 on room air was measured at rest and after 2 min of moderate exercise. HIT was conducted using fractional inspired oxygen concentration 0.14 and SpO2 was measured after equilibration of ≥ 5 min. The relationships between SpO2 during HIT (HIT SpO2) and resting SpO2, post-exercise SpO2, gas exchange (diffusing capacity for carbon monoxide) and ventilatory capacity were examined. Linear regression was performed to identify significant predictors of HIT SpO2. Results 137 patients were studied: 70 had chronic obstructive pulmonary disease, 43 interstitial lung disease and 20 extra-pulmonary restriction. All patients with HIT SpO2 ≤ 85% had post-exercise SpO2 < 95% (n = 24 (18%)). HIT SpO2 correlated best with post-exercise SpO2 overall (r = 0.69, P < 0.01). Linear regression identified forced vital capacity % predicted, resting SpO2 and post-exercise SpO2 as independent predictors of HIT SpO2. Conclusions In patients with respiratory disease, post-exercise SpO2 ≥ 95% on room air may be used to exclude the need for HIT to assess oxygen requirement for air travel. HIT SpO2 can be estimated from forced vital capacity % predicted, resting SpO2 and post-exercise SpO2 using a linear regression model." @default.
• W1516328542 created "2016-06-24" @default.
• W1516328542 creator A5029713849 @default.
• W1516328542 creator A5034844586 @default.
• W1516328542 creator A5039362263 @default.
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• W1516328542 date "2013-03-21" @default.
• W1516328542 modified "2023-10-01" @default.
• W1516328542 title "Vital capacity and oxygen saturation at rest and after exercise predict hypoxaemia during hypoxic inhalation test in patients with respiratory disease" @default.
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• W1516328542 doi "https://doi.org/10.1111/resp.12036" @default.
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