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• W1516368639 abstract "We studied the uptake of α-aminoisobutyric acid (AIB) in Streptococcus pyogenes and its physiologically isotonic L-form. S. pyogenes cells starved for glucose or treated with carbonyl cyanide- m -chlorophenyl hydrazone accumulated limited amounts of AIB. A high apparent K m value characterized the glucose-independent transport of AIB. The rate and extent of AIB accumulation significantly increased in the presence of glucose. Two saturable transport components with distinct apparent K m values characterized glycolysis-coupled transport of AIB. A biphasic Lineweaver-Burk plot was also obtained for l -alanine transport by glycolyzing S. pyogenes cells. AIB seems to share a common transport system(s) with glycine, l - and d -alanine, l -serine, and l -valine. This was shown by the competitive inhibition of AIB uptake by these compounds and their ability to induce competitive exchange efflux of accumulated AIB. About 30% of the AIB uptake was not inhibited by a saturating amount of l -valine, indicating the existence of more than one system for AIB transport. p -Chloromercuribenzoate markedly inhibited the accumulation of AIB by both glycolyzing and glucose-starved cells. In contrast, carbonyl cyanide- m -chlorophenyl hydrazone affected only metabolism-dependent uptake of AIB, which was also sensitive to dinitrophenol, N -ethylmaleimide, iodoacetate, fluoride (NaF), arsenate, and N,N ′-dicyclohexylcarbodiimide. These results are interpreted according to the chemiosmotic theory of Mitchell, whereby a proton motive force constitutes the driving force for AIB accumulation. AIB was not accumulated by the L-form. However, a temporary accumulation of AIB by a counterflow mechanism and a saturable system with a low apparent affinity were demonstrated for AIB transport by this organism. We suggest that a deficiency in the coupling of energy to AIB transport is responsible for the apparent lack of active AIB accumulation by the L-form." @default.
• W1516368639 created "2016-06-24" @default.
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• W1516368639 date "1982-01-01" @default.
• W1516368639 modified "2023-09-27" @default.
• W1516368639 title "Transport of α-Aminoisobutyric Acid by Streptococcus pyogenes and Its Derived L-Form" @default.
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• W1516368639 doi "https://doi.org/10.1128/jb.149.1.211-220.1982" @default.
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