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- W1516414621 abstract "This chapter reviews the data available on the structure and the biology of reactive astrocytes. It also reviews concepts such as the permissivity of reactive astrocytes for axonal regrowth and the antioxidant role of (reactive) astrocytes in neurodegenerative and traumatic damages. The astrocytes constitute one of the most important components in the biology of the brain. Many functions have attributed to astroglia, including nutritional and structural support during central nervous system (CNS) development, ion homeostasis, the uptake of neurotransmitters, contribution to the CNS immune system, and neuromodulation. Another role for astroglia is the preservation of the host tissue integrity following an injury, which is the property of activated astrocytes, called “reactive astrocytes.” Reactive gliosis is characterized by the hypertrophy of astrocytes and by the proliferation of microglial cells and astrocytes. Although reactive gliosis is considered to be the major impediment to axonal regrowth after an injury, the formation of a glial barrier around a lesion site is also a positive event because it isolates the still intact CNS tissue from secondary lesions." @default.
- W1516414621 created "2016-06-24" @default.
- W1516414621 creator A5059647237 @default.
- W1516414621 creator A5062387824 @default.
- W1516414621 date "2000-01-01" @default.
- W1516414621 modified "2023-09-27" @default.
- W1516414621 title "Reactive astrocytes, their roles in CNS injury, and repair mechanisms" @default.
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