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- W1516461831 abstract "OBJECTIVES: To compare different anatomical and functional aspects of Default Mode Network (DMN) in mild AD and in aMCI and to verify which of these variables are more affected in these diseases.BACKGROUND: Recent studies suggest that neurodegenerative diseases might be brain network diseases. DMN is a plausible candidate in AD.METHODS: We evaluated 25 mild AD, 23 aMCI and 27 controls (CTR) age/gender matched. All underwent 3T MRI to evaluate DMN: cortical thickness (GM), diffusion tensor imaging (fractional anisotropy-FA) in the cingulate and parahippocampal fasciculi and Functional Connectivity (FC- frontal and temporal subparts in relation to posterior cingulate cortex). We compared patients and controls in all these measures (GM, FA and FC). We also compared which of these measures were more affected in the patients groups.RESULTS: Comparisons between patients and controls: Temporal GM: AD < CTR (p=0.0003) and aMCI < CTR (p=0.035); Frontal GM: AD < aMCI (p=0.035). Frontal FC: AD < aMCI (p=0.024); Temporal FC: no differences. Cingulate FA: aMCI < AD (p=0.056) and AD < CTR (p=0.039). Parahippocampal FA: AD < CTR (p=0.038). Comparisons between FC, FA and GM measures in aMCI and AD: there is no significant difference between these methods in aMCI. In AD group, Temporal GM is more affected than FA (p=0.026) and than FC (p=0.006).CONCLUSIONS: AD spectrum affects different DMN aspects. In Temporal DMN subpart, cortical thickness differentiates AD and controls better than FA and FC. Disclosure: Dr. Balthazar has nothing to disclose. Dr. Weiler has nothing to disclose. Dr. Campos has nothing to disclose. Dr. Rezende has nothing to disclose. Dr. Damasceno has nothing to disclose. Dr. Cendes has nothing to disclose." @default.
- W1516461831 created "2016-06-24" @default.
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- W1516461831 date "2014-04-08" @default.
- W1516461831 modified "2023-09-30" @default.
- W1516461831 title "Alzheimer as a Default Mode Network Disease: A Grey Matter, Functional and Structural Connectivity Study (P6.324)" @default.
- W1516461831 hasPublicationYear "2014" @default.
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