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- W1516461966 endingPage "1478" @default.
- W1516461966 startingPage "1470" @default.
- W1516461966 abstract "The vascular endothelium of the blood–brain barrier (BBB) is regarded as a part of the neurovascular unit (NVU). This emerging NVU concept emphasizes the need for homeostatic signalling among the neuronal, glial and vascular endothelial cellular compartments in maintaining normal brain function. Conversely, dysfunction in any component of the NVU affects another, thus contributing to disease. Brain endothelial activation and dysfunction is observed in various neurological diseases, such as (ischemic) stroke, seizure, brain inflammation and infectious diseases and likely contributes to or exacerbates neurological conditions. The role and impact of brain endothelial factors on astroglial and neuronal activation is unclear. Similarly, it is not clear which stages of BBB endothelial activation can be considered beneficial versus detrimental. Although the BBB plays an important role in context of encephalopathies caused by neurotropic microbes that must first penetrate into the brain, a crucial role of the BBB in contributing to neurological dysfunction may be seen in cerebral malaria (CM), where the Plasmodium parasite remains sequestered in the brain vasculature, does not enter the brain parenchyma, and yet causes coma and seizures. In this minireview some of the scenarios and factors that may play a role in BBB as a relay station to modulate astroneuronal functioning are discussed." @default.
- W1516461966 created "2016-06-24" @default.
- W1516461966 creator A5019692144 @default.
- W1516461966 creator A5040424012 @default.
- W1516461966 creator A5049228932 @default.
- W1516461966 creator A5091293033 @default.
- W1516461966 date "2011-09-06" @default.
- W1516461966 modified "2023-09-27" @default.
- W1516461966 title "How can microbial interactions with the blood-brain barrier modulate astroglial and neuronal function?" @default.
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