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- W1516784387 abstract "The history of Mycobacterium tuberculosis (MTB) as the main agent of tuberculosis (TB) goes back a very long time. Fragments of the spinal column of Egyptian mummies from 2400 BCE (Before Common Era) show definite pathological signs of tubercular decay (Tripathi, Tewari et al., 2005). From that time to the present day millions have died of the disease and only a few drugs are active against the bacilli. Current data show an ancient disease more prevalent in the world today than at any other time in human history (Koul, Arnoult et al., 2011). Annually, TB is responsible for the death of two to three million people worldwide and global economic losses around $ 12 billion (Ma, Lienhardt et al., 2010). Approximately a third of the world’s population is estimated to be infected with MTB, giving rise to 9.4 million new cases of active TB disease each year (Zwerling, Behr et al., 2011). In addition, the highly resistant Multi-Drug-resistant (MDR) and Extensively-Drug-Resistant (XDR) MTB organisms are virtually untreatable in immunocompetent patients. So when these bacteria enter into contact with highly immunocompromised HIV-infected populations, the mortality rate reaches 100% within a few weeks of infection (Gandhi, Nunn et al., 2010)." @default.
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- W1516784387 date "2012-02-15" @default.
- W1516784387 modified "2023-10-16" @default.
- W1516784387 title "An Approach to the Search for New Drugs Against Tuberculosis" @default.
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- W1516784387 doi "https://doi.org/10.5772/31618" @default.
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