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- W1516831039 abstract "The relationship of folate transport and chemically induced differentiation of murine erythroleukemia cells (MELC) was examined. MELC were found to have a carrier-mediated transport system for reduced folates. Chemically induced differentiation of MELC caused a 10-fold decrease in the rate of influx of the folate analog methotrexate. The loss of methotrexate transport during differentiation resulted from a 15-fold decrease in the Vmax for the influx while the Km remained unchanged. Inducer dose dependencies for hemoglobin accumulation and loss of methotrexate influx were similar. A dimethyl sulfoxide-resistant variant of MELC did not express complete accumulation of hemoglobin or loss of methotrexate transport when treated with dimethyl sulfoxide. The decrease of folate influx during differentiation was not a result of: 1) changes in cell densities or growth phase; 2) growth-related changes of the medium; or 3) a direct inhibition of folate influx by the inducers. Loss of folate compound transport correlated with MELC differentiation." @default.
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- W1516831039 date "1984-01-01" @default.
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- W1516831039 title "Transport of the folate compound methotrexate decreases during differentiation of murine erythroleukemia cells." @default.
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- W1516831039 doi "https://doi.org/10.1016/s0021-9258(17)43642-8" @default.
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