FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1516906688> ?p ?o ?g. }

• W1516906688 endingPage "10602" @default.
• W1516906688 startingPage "10594" @default.
• W1516906688 abstract "Although all bipolar cells in the retina probably use the excitatory transmitter glutamate, approximately half of the cone bipolar cells also contain elevated levels of the inhibitory transmitter glycine. Some types of cone bipolar cells make heterologous gap junctions with rod amacrine cells, which contain elevated levels of glycine, leading to the hypothesis that the bipolar cells obtain their glycine from amacrine cells. Experimental support for this hypothesis is now provided by three independent lines of evidence. First, the glycine transporter GLYT1 is expressed by the glycine-containing amacrine cells but not by the glycine-containing bipolar cells, suggesting that only the amacrine cells are functionally glycinergic. Second, the gap-junction blocker carbenoxolone greatly reduces exogenous 3 H-glycine accumulation into the bipolar cells but not the amacrine cells. Moreover, when the endogenous glycine stores in both cell classes are depleted by incubating the retina with a glycine-uptake inhibitor, carbenoxolone blocks the subsequent glycine replenishment of the bipolar cells but not the amacrine cells. Third, intracellular injection of rod amacrine cells with the gap-junction permeant tracer Neurobiotin secondarily labels a heterogenous population of cone bipolar cells, all of which show glycine immunoreactivity. Taken together, these findings indicate that the elevated glycine in cone bipolar cells is not derived by high-affinity uptake or de novo synthesis but is obtained by neurotransmitter coupling through gap junctions with glycinergic amacrine cells. Thus transmitter content may be an unreliable indicator of transmitter function for neurons that make heterologous gap junctions." @default.
• W1516906688 created "2016-06-24" @default.
• W1516906688 creator A5023747665 @default.
• W1516906688 creator A5044769115 @default.
• W1516906688 creator A5072618108 @default.
• W1516906688 date "1998-12-15" @default.
• W1516906688 modified "2023-10-12" @default.
• W1516906688 title "Neurotransmitter Coupling through Gap Junctions in the Retina" @default.
• W1516906688 cites W1549420378 @default.
• W1516906688 cites W1578249395 @default.
• W1516906688 cites W16541135 @default.
• W1516906688 cites W1740455381 @default.
• W1516906688 cites W1852646540 @default.
• W1516906688 cites W1865596632 @default.
• W1516906688 cites W1912265148 @default.
• W1516906688 cites W1934020811 @default.
• W1516906688 cites W1958166723 @default.
• W1516906688 cites W1968740148 @default.
• W1516906688 cites W1969353558 @default.
• W1516906688 cites W1972006822 @default.
• W1516906688 cites W1979845443 @default.
• W1516906688 cites W1987391644 @default.
• W1516906688 cites W1998785190 @default.
• W1516906688 cites W2003564852 @default.
• W1516906688 cites W2026926482 @default.
• W1516906688 cites W2034852042 @default.
• W1516906688 cites W2040247477 @default.
• W1516906688 cites W2040425611 @default.
• W1516906688 cites W2040441118 @default.
• W1516906688 cites W2044959126 @default.
• W1516906688 cites W2047036345 @default.
• W1516906688 cites W2047927531 @default.
• W1516906688 cites W2047946144 @default.
• W1516906688 cites W2048259616 @default.
• W1516906688 cites W2050251438 @default.
• W1516906688 cites W2063471775 @default.
• W1516906688 cites W2072759014 @default.
• W1516906688 cites W2073863281 @default.
• W1516906688 cites W2076374143 @default.
• W1516906688 cites W2076880531 @default.
• W1516906688 cites W2079669147 @default.
• W1516906688 cites W2081678712 @default.
• W1516906688 cites W2085579547 @default.
• W1516906688 cites W2087538286 @default.
• W1516906688 cites W2089071333 @default.
• W1516906688 cites W2095018051 @default.
• W1516906688 cites W2099241014 @default.
• W1516906688 cites W2126906616 @default.
• W1516906688 cites W2136867476 @default.
• W1516906688 cites W2149577129 @default.
• W1516906688 cites W2168509949 @default.
• W1516906688 cites W2172144144 @default.
• W1516906688 cites W2337516134 @default.
• W1516906688 cites W23975521 @default.
• W1516906688 cites W2413626083 @default.
• W1516906688 cites W4252517265 @default.
• W1516906688 doi "https://doi.org/10.1523/jneurosci.18-24-10594.1998" @default.
• W1516906688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6793342" @default.
• W1516906688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9852595" @default.
• W1516906688 hasPublicationYear "1998" @default.
• W1516906688 type Work @default.
• W1516906688 sameAs 1516906688 @default.
• W1516906688 citedByCount "140" @default.
• W1516906688 countsByYear W15169066882012 @default.
• W1516906688 countsByYear W15169066882013 @default.
• W1516906688 countsByYear W15169066882014 @default.
• W1516906688 countsByYear W15169066882015 @default.
• W1516906688 countsByYear W15169066882016 @default.
• W1516906688 countsByYear W15169066882017 @default.
• W1516906688 countsByYear W15169066882018 @default.
• W1516906688 countsByYear W15169066882019 @default.
• W1516906688 countsByYear W15169066882020 @default.
• W1516906688 countsByYear W15169066882021 @default.
• W1516906688 countsByYear W15169066882022 @default.
• W1516906688 crossrefType "journal-article" @default.
• W1516906688 hasAuthorship W1516906688A5023747665 @default.
• W1516906688 hasAuthorship W1516906688A5044769115 @default.
• W1516906688 hasAuthorship W1516906688A5072618108 @default.
• W1516906688 hasBestOaLocation W15169066881 @default.
• W1516906688 hasConcept C12554922 @default.
• W1516906688 hasConcept C158157758 @default.
• W1516906688 hasConcept C169760540 @default.
• W1516906688 hasConcept C2776219046 @default.
• W1516906688 hasConcept C2777093970 @default.
• W1516906688 hasConcept C2777756961 @default.
• W1516906688 hasConcept C2778658801 @default.
• W1516906688 hasConcept C2780961449 @default.
• W1516906688 hasConcept C35599011 @default.
• W1516906688 hasConcept C515207424 @default.
• W1516906688 hasConcept C529278444 @default.
• W1516906688 hasConcept C55493867 @default.
• W1516906688 hasConcept C79879829 @default.
• W1516906688 hasConcept C86803240 @default.
• W1516906688 hasConcept C95444343 @default.
• W1516906688 hasConceptScore W1516906688C12554922 @default.
• W1516906688 hasConceptScore W1516906688C158157758 @default.
• W1516906688 hasConceptScore W1516906688C169760540 @default.
• W1516906688 hasConceptScore W1516906688C2776219046 @default.

• next