Matches in SemOpenAlex for { <https://semopenalex.org/work/W1516926411> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1516926411 endingPage "452" @default.
- W1516926411 startingPage "445" @default.
- W1516926411 abstract "BACKGROUND Gromwell is known to have diverse pharmacological, cosmetic and nutritional benefits for humans. Nevertheless, the biological influence of gromwell extract (GE) on the general physiology of eukaryotic cells remains unknown. In this study a global transcriptome analysis was performed to identify genes affected by the addition of GE with Cryptococcus neoformans as the model system. RESULTS In response to GE treatment, genes involved in signal transduction were immediately regulated, and the evolutionarily conserved sets of genes involved in the core cellular functions, including DNA replication, RNA transcription/processing and protein translation/processing, were generally up-regulated. In contrast, a number of genes involved in carbohydrate metabolism and transport, inorganic ion transport and metabolism, post-translational modification/protein turnover/chaperone functions and signal transduction were down-regulated. Among the GE-responsive genes that are also evolutionarily conserved in the human genome, the expression patterns of YSA1, TPO2, CFO1 and PZF1 were confirmed by northern blot analysis. Based on the functional characterization of some GE-responsive genes, it was found that GE treatment may promote cellular tolerance against a variety of environmental stresses in eukaryotes. CONCLUSIONS GE treatment affects the expression levels of a significant portion of the Cryptococcus genome, implying that GE significantly affects the general physiology of eukaryotic cells. © 2013 Society of Chemical Industry" @default.
- W1516926411 created "2016-06-24" @default.
- W1516926411 creator A5013212963 @default.
- W1516926411 creator A5037701450 @default.
- W1516926411 creator A5051546694 @default.
- W1516926411 creator A5082412878 @default.
- W1516926411 creator A5083730613 @default.
- W1516926411 date "2013-07-17" @default.
- W1516926411 modified "2023-09-28" @default.
- W1516926411 title "Global transcriptome analysis of eukaryotic genes affected by gromwell extract" @default.
- W1516926411 cites W1573408757 @default.
- W1516926411 cites W1973010471 @default.
- W1516926411 cites W2001430852 @default.
- W1516926411 cites W2075254108 @default.
- W1516926411 cites W2091212435 @default.
- W1516926411 cites W2092686628 @default.
- W1516926411 cites W2098372519 @default.
- W1516926411 cites W2109085633 @default.
- W1516926411 cites W2110382452 @default.
- W1516926411 cites W2114043874 @default.
- W1516926411 cites W2146523084 @default.
- W1516926411 doi "https://doi.org/10.1002/jsfa.6265" @default.
- W1516926411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23765595" @default.
- W1516926411 hasPublicationYear "2013" @default.
- W1516926411 type Work @default.
- W1516926411 sameAs 1516926411 @default.
- W1516926411 citedByCount "3" @default.
- W1516926411 countsByYear W15169264112014 @default.
- W1516926411 countsByYear W15169264112017 @default.
- W1516926411 crossrefType "journal-article" @default.
- W1516926411 hasAuthorship W1516926411A5013212963 @default.
- W1516926411 hasAuthorship W1516926411A5037701450 @default.
- W1516926411 hasAuthorship W1516926411A5051546694 @default.
- W1516926411 hasAuthorship W1516926411A5082412878 @default.
- W1516926411 hasAuthorship W1516926411A5083730613 @default.
- W1516926411 hasConcept C104317684 @default.
- W1516926411 hasConcept C141231307 @default.
- W1516926411 hasConcept C150194340 @default.
- W1516926411 hasConcept C162317418 @default.
- W1516926411 hasConcept C18431079 @default.
- W1516926411 hasConcept C2777893358 @default.
- W1516926411 hasConcept C54355233 @default.
- W1516926411 hasConcept C62478195 @default.
- W1516926411 hasConcept C67705224 @default.
- W1516926411 hasConcept C70721500 @default.
- W1516926411 hasConcept C86803240 @default.
- W1516926411 hasConcept C95444343 @default.
- W1516926411 hasConceptScore W1516926411C104317684 @default.
- W1516926411 hasConceptScore W1516926411C141231307 @default.
- W1516926411 hasConceptScore W1516926411C150194340 @default.
- W1516926411 hasConceptScore W1516926411C162317418 @default.
- W1516926411 hasConceptScore W1516926411C18431079 @default.
- W1516926411 hasConceptScore W1516926411C2777893358 @default.
- W1516926411 hasConceptScore W1516926411C54355233 @default.
- W1516926411 hasConceptScore W1516926411C62478195 @default.
- W1516926411 hasConceptScore W1516926411C67705224 @default.
- W1516926411 hasConceptScore W1516926411C70721500 @default.
- W1516926411 hasConceptScore W1516926411C86803240 @default.
- W1516926411 hasConceptScore W1516926411C95444343 @default.
- W1516926411 hasIssue "3" @default.
- W1516926411 hasLocation W15169264111 @default.
- W1516926411 hasLocation W15169264112 @default.
- W1516926411 hasOpenAccess W1516926411 @default.
- W1516926411 hasPrimaryLocation W15169264111 @default.
- W1516926411 hasRelatedWork W1603543036 @default.
- W1516926411 hasRelatedWork W1971124177 @default.
- W1516926411 hasRelatedWork W1976510917 @default.
- W1516926411 hasRelatedWork W2009966535 @default.
- W1516926411 hasRelatedWork W2069184423 @default.
- W1516926411 hasRelatedWork W2102579905 @default.
- W1516926411 hasRelatedWork W3089353767 @default.
- W1516926411 hasRelatedWork W4213265720 @default.
- W1516926411 hasRelatedWork W4247273247 @default.
- W1516926411 hasRelatedWork W2187207551 @default.
- W1516926411 hasVolume "94" @default.
- W1516926411 isParatext "false" @default.
- W1516926411 isRetracted "false" @default.
- W1516926411 magId "1516926411" @default.
- W1516926411 workType "article" @default.