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- W1517076645 abstract "During incubation of ZXd2, an insoluble intermediate of the properdin system, with properdin factors D and B a complex forms, designated ZX, which cleaves purified C3. Factor D is replaceable in this system by proteolytic enzymes, e.g., trypsin, pronase or plasmin. ZX formation with ZXd2, factor B and factor D or trypsin requires the presence of Mg++. ZX complexes formed either with factor D or with trypsin are identical with respect to their stability in the absence of divalent cations and with respect to the decay of the C3-cleaving enzymes. From the data obtained with proteolytic enzymes it is concluded that factor D acts as a protease in the formation of ZX. Sequential studies of ZX formation revealed that factor B binds reversibly to ZXd2 in the presence of Mg++. The resulting ZXd2 B complex was found to acquire enzymatic activity against C3 after treatment with factor D or trypsin. Our data suggest that in the ZXd2 system two steps are involved in ZX formation, namely binding of factor B to a receptor on ZXd2, probably C3b, which occurs only in the presence of Mg++, and subsequent proteolytic activation of this complex which is Mg++-independent." @default.
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- W1517076645 date "1974-12-01" @default.
- W1517076645 modified "2023-09-23" @default.
- W1517076645 title "Formation of the C3-cleaving properdin enzyme on zymosan. Demonstration that factor D is replaceable by proteolytic enzymes." @default.
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