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- W1517117470 abstract "High penetrance mutations in several tumor predisposition genes have been identified that contribute to different hereditary cancer syndromes. Many of these mutations follow an autosomal dominant mode of inheritance, thus predisposition carriers are often found in subsequent generations. For several tumor predisposition genes, the basic mechanisms they play in cancer pathogenesis are well understood, however, several questions remain. Extensive research is still needed to uncover the molecular basis of phenomena such as reduced penetrance, cell-type specificity, and variability of associated clinical features." @default.
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- W1517117470 date "2008-12-17" @default.
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- W1517117470 title "The Genetic Background of Hereditary Tumor Diseases" @default.
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