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- W1517163622 abstract "Some of the biological properties of 3T3 cells transformed by Ts-a, a thermosensitive mutant of polyoma virus, have been studied. The transformed cells maintain their transformed phenotype if propagated at the non-permissive temperature (38.5 °C); if shifted to 31 °C, the permissive temperature for virus growth, a variable proportion of the cells in the culture produce virus. The fraction of productive cells at 31 °C increases with time as long as the cultures are actively growing, suggesting a close association between cell growth and the processes leading to virus production. The availability of a transformed line which can be induced to produce virus under certain conditions provides a useful tool for the study of the state of the viral genome in transformed cells." @default.
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- W1517163622 date "1970-02-01" @default.
- W1517163622 modified "2023-09-23" @default.
- W1517163622 title "Induction of virus multiplication in 3T3 cells transformed by a thermosensitive mutant of polyoma virus" @default.
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- W1517163622 doi "https://doi.org/10.1016/0022-2836(70)90304-9" @default.
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