Matches in SemOpenAlex for { <https://semopenalex.org/work/W151718343> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W151718343 abstract "Breast cancer is among of the frequently diagnosed cancer and causes high mortality rate in most countries in the world. These led to the necessity for the development of potential chemotherapeutic agents against breast cancer cells with novel mechanisms of actions. The plant-derived triterpenoids commonly used due to its ability to exhibit cytotoxicity against a variety of tumor cells. Luvunga scandens (Rutaceae) is one of the plants that contain triterpenoids. L. scandens was extracted and assayed on human breast adenocarcinoma cell line (MCF-7). The stems of L. scandens were extracted with n-hexane, dichloromethane (DCM) and ethanol (EtOH). DCM extracts were then further fractionated by vacuum liquid chromatography (VLC) into five extracts; namely n-hexane, n-hexane:DCM, DCM, DCM:MeOH and MeOH. Those five extracts were assayed in vitro cytototoxic activity against MCF-7. Among them, DCM:MeOH fraction was found to be the most effective and was further subjected to isolation procedure and the isolated compound was assayed in vitro cytotoxic activity against MCF-7. Bioactivity-guided fractionation of the fraction through successive column chromatography procedures led to the isolation of a triterpene-type of compounds. The structure of the compound was elucidated to be lanosta-8, 24-dien-21-oicacid, 3-oxo, (13a, 14b, 17a, 20S) with molecular formula of C3OH46O3. This compound was found to be responsible for the cytotoxicity effects with the IC50 value of 24.8 μM. Whereas IC50 of DCM extract and DCM:MeOH fraction extract is 75 and 94 μg/ml respectively. Therefore, it revealed that L. scandens is potential sources of cytotoxic agents." @default.
- W151718343 created "2016-06-24" @default.
- W151718343 creator A5008553322 @default.
- W151718343 creator A5010757863 @default.
- W151718343 creator A5011841851 @default.
- W151718343 creator A5080172776 @default.
- W151718343 date "2014-03-01" @default.
- W151718343 modified "2023-09-22" @default.
- W151718343 title "Cytotoxic agents from luvunga scandens human breast adenocarcinoma cell line (MCF-7)" @default.
- W151718343 hasPublicationYear "2014" @default.
- W151718343 type Work @default.
- W151718343 sameAs 151718343 @default.
- W151718343 citedByCount "0" @default.
- W151718343 crossrefType "journal-article" @default.
- W151718343 hasAuthorship W151718343A5008553322 @default.
- W151718343 hasAuthorship W151718343A5010757863 @default.
- W151718343 hasAuthorship W151718343A5011841851 @default.
- W151718343 hasAuthorship W151718343A5080172776 @default.
- W151718343 hasConcept C109316439 @default.
- W151718343 hasConcept C109541995 @default.
- W151718343 hasConcept C121608353 @default.
- W151718343 hasConcept C142724271 @default.
- W151718343 hasConcept C154317977 @default.
- W151718343 hasConcept C185592680 @default.
- W151718343 hasConcept C202751555 @default.
- W151718343 hasConcept C204787440 @default.
- W151718343 hasConcept C2777077568 @default.
- W151718343 hasConcept C2777752497 @default.
- W151718343 hasConcept C2780400988 @default.
- W151718343 hasConcept C2780471494 @default.
- W151718343 hasConcept C2780527577 @default.
- W151718343 hasConcept C2781182431 @default.
- W151718343 hasConcept C2994423619 @default.
- W151718343 hasConcept C43617362 @default.
- W151718343 hasConcept C530470458 @default.
- W151718343 hasConcept C54355233 @default.
- W151718343 hasConcept C55493867 @default.
- W151718343 hasConcept C556039675 @default.
- W151718343 hasConcept C71240020 @default.
- W151718343 hasConcept C71924100 @default.
- W151718343 hasConcept C86803240 @default.
- W151718343 hasConcept C97428945 @default.
- W151718343 hasConceptScore W151718343C109316439 @default.
- W151718343 hasConceptScore W151718343C109541995 @default.
- W151718343 hasConceptScore W151718343C121608353 @default.
- W151718343 hasConceptScore W151718343C142724271 @default.
- W151718343 hasConceptScore W151718343C154317977 @default.
- W151718343 hasConceptScore W151718343C185592680 @default.
- W151718343 hasConceptScore W151718343C202751555 @default.
- W151718343 hasConceptScore W151718343C204787440 @default.
- W151718343 hasConceptScore W151718343C2777077568 @default.
- W151718343 hasConceptScore W151718343C2777752497 @default.
- W151718343 hasConceptScore W151718343C2780400988 @default.
- W151718343 hasConceptScore W151718343C2780471494 @default.
- W151718343 hasConceptScore W151718343C2780527577 @default.
- W151718343 hasConceptScore W151718343C2781182431 @default.
- W151718343 hasConceptScore W151718343C2994423619 @default.
- W151718343 hasConceptScore W151718343C43617362 @default.
- W151718343 hasConceptScore W151718343C530470458 @default.
- W151718343 hasConceptScore W151718343C54355233 @default.
- W151718343 hasConceptScore W151718343C55493867 @default.
- W151718343 hasConceptScore W151718343C556039675 @default.
- W151718343 hasConceptScore W151718343C71240020 @default.
- W151718343 hasConceptScore W151718343C71924100 @default.
- W151718343 hasConceptScore W151718343C86803240 @default.
- W151718343 hasConceptScore W151718343C97428945 @default.
- W151718343 hasLocation W1517183431 @default.
- W151718343 hasOpenAccess W151718343 @default.
- W151718343 hasPrimaryLocation W1517183431 @default.
- W151718343 hasRelatedWork W140360903 @default.
- W151718343 hasRelatedWork W2021784935 @default.
- W151718343 hasRelatedWork W2055160578 @default.
- W151718343 hasRelatedWork W2120399463 @default.
- W151718343 hasRelatedWork W2520711811 @default.
- W151718343 hasRelatedWork W2594502382 @default.
- W151718343 hasRelatedWork W2601648610 @default.
- W151718343 hasRelatedWork W2770238079 @default.
- W151718343 hasRelatedWork W2781351128 @default.
- W151718343 hasRelatedWork W2796038551 @default.
- W151718343 hasRelatedWork W2891880776 @default.
- W151718343 hasRelatedWork W2892171744 @default.
- W151718343 hasRelatedWork W2915710345 @default.
- W151718343 hasRelatedWork W3036106142 @default.
- W151718343 hasRelatedWork W3042373019 @default.
- W151718343 hasRelatedWork W3134918209 @default.
- W151718343 hasRelatedWork W3168791775 @default.
- W151718343 hasRelatedWork W3192931095 @default.
- W151718343 hasRelatedWork W3202669214 @default.
- W151718343 hasRelatedWork W639986943 @default.
- W151718343 isParatext "false" @default.
- W151718343 isRetracted "false" @default.
- W151718343 magId "151718343" @default.
- W151718343 workType "article" @default.