FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1517194927> ?p ?o ?g. }

• W1517194927 abstract "Globally, ovarian cancer is the 6th most common malignancy in developed countries, responsible for 100,300 new cases and 64,500 deaths annually (Jemal et al., 2011). Approximately 90% of ovarian cancers arise within the ovarian surface epithelium (OSE) or the fallopian tube surface epithelium; the remainder of ovarian malignancies develops from other ovarian tissues (sex cord-stromal, germ cell, or mixed cell tumors). The overall prognosis for epithelial ovarian carcinoma (EOC) is poor: Diagnosis is typically late-stage due to the lack of effective screening methods and vague presenting symptoms, with 5-year survival at 40% for stage III and 20% for stage IV patients (Heintz et al., 2006). Despite excellent initial activity, the standard treatment consisting of cytoreductive surgery followed by platinumand taxane-based chemotherapy often fails with a recurrence rate of over 80% in stage III and IV disease. Therefore, novel therapeutic approaches are needed to improve the outcomes in this population. Research efforts have yielded insight into the etiology, signaling mechanisms, and progression of ovarian cancer, yet much remains poorly understood. Physiologically, steroid hormones are intimately involved in ovulation, reproduction, and function of normal OSE cells. There is growing evidence that estrogen, progesterone, and other hormones also play a role in the development and progression of ovarian cancer (Leung & Choi, 2007). “Incessant ovulation” with repetitive injury and repair of OSE and subsequent cumulative DNA damage is one of the hypothesized risk factors for ovarian cancer (Fathalla, 1971), yet this does not explain the occurrence of the majority of ovarian carcinomas well after the reproductive years (Berek & Hacker, 2010). Interestingly, although oral contraceptives (OCs), increasing parity, and prolonged breastfeeding all decrease cumulative risk (Gwinn et al., 1990; Risch et al., 1994), progestin-only contraceptives offer just as much protective benefit as estrogen-containing OCs without prohibiting ovulation (Risch, 1998). Another hypothesis for the development of ovarian cancer, the “gonadotropin hypothesis,” stipulates that gonadotropins contribute to ovarian carcinogenesis through follicle stimulating hormone (FSH)and luteinizing hormone (LH)-mediated excess stimulation of ovarian tissue. This hypothesis is consistent with the protective effect of OCs, and the observation that the majority of cases of epithelial ovarian cancer develop postmenopausally after a surge in gonadotropin levels. In vitro, gonadotropins such as FSH activate mitogenic pathways and stimulate ovarian epithelial cell proliferation (Choi et al., 2002). In addition to gonadotropins, excess androgens and estrogen have also been linked to the progression and possibly development of ovarian cancer. In vivo treatment of mice with" @default.
• W1517194927 created "2016-06-24" @default.
• W1517194927 creator A5018745283 @default.
• W1517194927 creator A5066564517 @default.
• W1517194927 date "2011-10-19" @default.
• W1517194927 modified "2023-10-17" @default.
• W1517194927 title "Steroid Hormones and Ovarian Cancer" @default.
• W1517194927 cites W138983148 @default.
• W1517194927 cites W1572759790 @default.
• W1517194927 cites W1777137221 @default.
• W1517194927 cites W1817833980 @default.
• W1517194927 cites W1840787377 @default.
• W1517194927 cites W1951785345 @default.
• W1517194927 cites W1965254544 @default.
• W1517194927 cites W1967387654 @default.
• W1517194927 cites W1969870046 @default.
• W1517194927 cites W1970436598 @default.
• W1517194927 cites W1971109330 @default.
• W1517194927 cites W1974005706 @default.
• W1517194927 cites W1974841944 @default.
• W1517194927 cites W1975673721 @default.
• W1517194927 cites W1976648955 @default.
• W1517194927 cites W1978130741 @default.
• W1517194927 cites W1979648005 @default.
• W1517194927 cites W1981740467 @default.
• W1517194927 cites W1982211279 @default.
• W1517194927 cites W1983325151 @default.
• W1517194927 cites W1985420164 @default.
• W1517194927 cites W1987965169 @default.
• W1517194927 cites W1991318732 @default.
• W1517194927 cites W1994439130 @default.
• W1517194927 cites W1995055473 @default.
• W1517194927 cites W1995165487 @default.
• W1517194927 cites W1995462407 @default.
• W1517194927 cites W1996746336 @default.
• W1517194927 cites W1996749548 @default.
• W1517194927 cites W1998172746 @default.
• W1517194927 cites W1999754181 @default.
• W1517194927 cites W2000907925 @default.
• W1517194927 cites W2000913167 @default.
• W1517194927 cites W2001416462 @default.
• W1517194927 cites W2002419309 @default.
• W1517194927 cites W2005140082 @default.
• W1517194927 cites W2006019492 @default.
• W1517194927 cites W2008797688 @default.
• W1517194927 cites W2009971333 @default.
• W1517194927 cites W2011471691 @default.
• W1517194927 cites W2011749889 @default.
• W1517194927 cites W2011963608 @default.
• W1517194927 cites W2012017918 @default.
• W1517194927 cites W2012052477 @default.
• W1517194927 cites W2014284922 @default.
• W1517194927 cites W2018231835 @default.
• W1517194927 cites W2019033573 @default.
• W1517194927 cites W2019279964 @default.
• W1517194927 cites W2022102157 @default.
• W1517194927 cites W2022867038 @default.
• W1517194927 cites W2023975343 @default.
• W1517194927 cites W2024384404 @default.
• W1517194927 cites W2024408861 @default.
• W1517194927 cites W2025119471 @default.
• W1517194927 cites W2027509121 @default.
• W1517194927 cites W2028957814 @default.
• W1517194927 cites W2029268506 @default.
• W1517194927 cites W2029327979 @default.
• W1517194927 cites W2029587031 @default.
• W1517194927 cites W2030462220 @default.
• W1517194927 cites W2032622871 @default.
• W1517194927 cites W2035066075 @default.
• W1517194927 cites W2035201807 @default.
• W1517194927 cites W2036850058 @default.
• W1517194927 cites W2038766067 @default.
• W1517194927 cites W2039198739 @default.
• W1517194927 cites W2041623560 @default.
• W1517194927 cites W2041683545 @default.
• W1517194927 cites W2043600485 @default.
• W1517194927 cites W2044497664 @default.
• W1517194927 cites W2044716671 @default.
• W1517194927 cites W2047974520 @default.
• W1517194927 cites W2052266277 @default.
• W1517194927 cites W2052745112 @default.
• W1517194927 cites W2053885863 @default.
• W1517194927 cites W2054807534 @default.
• W1517194927 cites W2059213440 @default.
• W1517194927 cites W2063947287 @default.
• W1517194927 cites W2066369543 @default.
• W1517194927 cites W2067353346 @default.
• W1517194927 cites W2069662317 @default.
• W1517194927 cites W2073219073 @default.
• W1517194927 cites W2074835867 @default.
• W1517194927 cites W2075506379 @default.
• W1517194927 cites W2075668200 @default.
• W1517194927 cites W2077714496 @default.
• W1517194927 cites W2080321597 @default.
• W1517194927 cites W2081479274 @default.
• W1517194927 cites W2084688538 @default.
• W1517194927 cites W2087023994 @default.
• W1517194927 cites W2087109466 @default.
• W1517194927 cites W2087416009 @default.
• W1517194927 cites W2087590552 @default.

• next