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- W1517283793 endingPage "3783" @default.
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- W1517283793 abstract "The postmortem Alzheimer's disease brain is characterized histochemically by the presence of extracellular amyloid plaques and neurofibrillary tangles. Also consistent with the disease is evidence for chronic oxidative damage within the brain. Considerable research data indicates that these three critical aspects of Alzheimer's disease are interdependent, raising the possibility that they share some commonality with respect to the ever elusive initial factor(s) that triggers the development of Alzheimer's disease. Here, we discuss reports that show a loss of metal homeostasis is also an important event in Alzheimer's disease, and we identify how metal dyshomeostasis may contribute to development of the amyloid-beta, tau and oxidative stress biology of Alzheimer's disease. We propose that therapeutic agents designed to modulate metal bio-availability have the potential to ameliorate several of the dysfunctional events characteristic of Alzheimer's disease. Metal-based therapeutics have already provided promising results for the treatment of Alzheimer's disease, and new generations of pharmaceuticals are being developed. In this review, we focus on copper dyshomeostasis in Alzheimer's disease, but we also discuss zinc and iron." @default.
- W1517283793 created "2016-06-24" @default.
- W1517283793 creator A5026838566 @default.
- W1517283793 creator A5038374630 @default.
- W1517283793 creator A5045915090 @default.
- W1517283793 date "2007-07-06" @default.
- W1517283793 modified "2023-10-18" @default.
- W1517283793 title "The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease" @default.
- W1517283793 cites W1501075116 @default.
- W1517283793 cites W1601433695 @default.
- W1517283793 cites W1707143272 @default.
- W1517283793 cites W1731253253 @default.
- W1517283793 cites W1894541755 @default.
- W1517283793 cites W1956314911 @default.
- W1517283793 cites W1963735892 @default.
- W1517283793 cites W1966618264 @default.
- W1517283793 cites W1969979382 @default.
- W1517283793 cites W1972456354 @default.
- W1517283793 cites W1972543492 @default.
- W1517283793 cites W1972928350 @default.
- W1517283793 cites W1981471614 @default.
- W1517283793 cites W1984924722 @default.
- W1517283793 cites W1985053970 @default.
- W1517283793 cites W1986384924 @default.
- W1517283793 cites W1988107440 @default.
- W1517283793 cites W1989354095 @default.
- W1517283793 cites W1992491411 @default.
- W1517283793 cites W1994151063 @default.
- W1517283793 cites W1996579240 @default.
- W1517283793 cites W1997805873 @default.
- W1517283793 cites W1998440070 @default.
- W1517283793 cites W2001111653 @default.
- W1517283793 cites W2002946614 @default.
- W1517283793 cites W2005729509 @default.
- W1517283793 cites W2006909664 @default.
- W1517283793 cites W2007003497 @default.
- W1517283793 cites W2009833553 @default.
- W1517283793 cites W2011574003 @default.
- W1517283793 cites W2012171863 @default.
- W1517283793 cites W2017797090 @default.
- W1517283793 cites W2018333394 @default.
- W1517283793 cites W2019511555 @default.
- W1517283793 cites W2024166316 @default.
- W1517283793 cites W2026536857 @default.
- W1517283793 cites W2027936955 @default.
- W1517283793 cites W2028346440 @default.
- W1517283793 cites W2032350023 @default.
- W1517283793 cites W2035089473 @default.
- W1517283793 cites W2036755018 @default.
- W1517283793 cites W2037387044 @default.
- W1517283793 cites W2037595129 @default.
- W1517283793 cites W2039069312 @default.
- W1517283793 cites W2039517040 @default.
- W1517283793 cites W2044627978 @default.
- W1517283793 cites W2046847750 @default.
- W1517283793 cites W2047219385 @default.
- W1517283793 cites W2047406096 @default.
- W1517283793 cites W2051516838 @default.
- W1517283793 cites W2052120254 @default.
- W1517283793 cites W2052559661 @default.
- W1517283793 cites W2052987925 @default.
- W1517283793 cites W2056924591 @default.
- W1517283793 cites W2058936552 @default.
- W1517283793 cites W2062751701 @default.
- W1517283793 cites W2063281989 @default.
- W1517283793 cites W2067144379 @default.
- W1517283793 cites W2070214311 @default.
- W1517283793 cites W2073900020 @default.
- W1517283793 cites W2079183347 @default.
- W1517283793 cites W2079190863 @default.
- W1517283793 cites W2083500052 @default.
- W1517283793 cites W2094808560 @default.
- W1517283793 cites W2097292535 @default.
- W1517283793 cites W2103440561 @default.
- W1517283793 cites W2113472155 @default.
- W1517283793 cites W2121042833 @default.
- W1517283793 cites W2121963977 @default.
- W1517283793 cites W2125805609 @default.
- W1517283793 cites W2126898944 @default.
- W1517283793 cites W2128389187 @default.
- W1517283793 cites W2129224791 @default.
- W1517283793 cites W2129900289 @default.
- W1517283793 cites W2131181742 @default.
- W1517283793 cites W2143582172 @default.
- W1517283793 cites W2143643970 @default.
- W1517283793 cites W2149278013 @default.
- W1517283793 cites W2150999725 @default.
- W1517283793 cites W2157935345 @default.
- W1517283793 cites W2162184782 @default.
- W1517283793 cites W2167425173 @default.
- W1517283793 cites W2168025729 @default.
- W1517283793 cites W4296154147 @default.
- W1517283793 cites W4296941341 @default.
- W1517283793 cites W65097477 @default.
- W1517283793 doi "https://doi.org/10.1111/j.1742-4658.2007.05918.x" @default.
- W1517283793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17617225" @default.
- W1517283793 hasPublicationYear "2007" @default.
- W1517283793 type Work @default.